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Product DNA polymerase I
| DNA polymerase I |
involvedin joining Okazaki frags,in gap-filling during DNA repair, in strand Xch. Has polymerase act.,5 to 3' exonuclease removing 5' DNA or RNA, 3' to 5' exo that edits '2 termini of nascent DNA. No PolI makes cell UV sens.Del.lethal in rich not min.med
- Zhang, W., D.H. Evans 1995. DNA strand transfer catalyzed by the 5'-3' exonuclease domain of Escherichia coli DNA polymerase I. Nucleic Acids Res. 23:4620-4627
- Tuske, S., K. Singh, N. Kaushik, M.J. Modak 2000. The J-helix of Escherichia coli DNA polymerase I (Klenow fragment) regulates polymerase and 3'- 5'-exonuclease functions. J.Biol.Chem. 275:23759-68
- Morales, J.C., E.T. Kool 2000. Importance of terminal base pair hydrogen-bonding in 3'-end proofreading by the Klenow fragment of DNA polymerase I. Biochemistry 39:2626-2632
- Shinkai, A., L.A. Loeb 2001. In vivo mutagenesis by Escherichia coli DNA polymerase I.Ile(709) in motif A functions in base selection. J.Biol.Chem. 276:46759-46764
- Zhuang, P., A. Kolbanovskiy, S. Amin, N.E. Geacintov 2001. Base sequence dependence of in vitro translesional DNA replication past a bulky lesion catalyzed by the exo- Klenow fragment of Pol I. Biochemistry 40:6660-6669
- Brakmann, S., P. Nieckchen 2001. The large fragment of Escherichia coli DNA polymerase I can synthesize DNA exclusively from fluorescently labeled nucleotides. Chembiochem 2:773-777
- Alekseyev, Y.O., L.J. Romano 2002. Effects of benzo[a]pyrene adduct stereochemistry on downstream DNA replication in vitro: evidence for different adduct conformations within the active site of DNA polymerase I (Klenow fragment). Biochemistry 41:4467-4