Site ruvA
- Name: ruvA
- Type: Gene
- Synonyms
b1861 MG1655 locus tag - Mnemonic: repair uv?
- Left End Point: 41.89
- Right End Point: 41.90
- Products:
DNA binding protein RuvAB - Direction: <
- Properties:
Property Comment lexA regulon NULL SOS-related induced as part of SOS response - Priority: 1
- 4 Alleles of This Gene
ruvA200 ruvA4 ruvA60(polar)::Tn10 ruvA786(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10923 EcoliWiki ruvA - Comment:
- Filament formation and sensitivity to UV. RuvA and B promote formation of heteroduplex DNA by catalyzing branch mig.of Holliday junctions/crossovers (requires SSB).
- References:
- Shurvinton, C.E., R.G. Lloyd, F.E. Benson, P.V. Attfield 1984. Genetic analysis and molecular cloning of the Escherichia coli ruv gene. Mol.Gen.Genet. 194:322-329
- Attfield, P.V., F.E. Benson, R.G. Lloyd 1985. Analysis of the ruv locus of Escherichia coli K-12 and identification of the gene product. J.Bacteriol. 164:276-281
- Benson, F.E., G.T. Illing, G.J. Sharples, R.G. Lloyd 1988. Nucleotide sequencing of the ruv region of Escherichia coli K-12 reveals a LexA regulated operon encoding two genes. Nucleic Acids Res. 16:1541-1549
- Iwasaki, H., T. Shiba, A. Nakata, H. Shinagawa 1989. Involvement in DNA repair of the ruvA gene of Escherichia coli. Mol.Gen.Genet. 219:328-331
- Benson, F., S. Collier, R.G. Lloyd 1991. Evidence of abortive recombination in ruv mutants of Escherichia coli K12. Mol.Gen.Genet. 225:266-272
- Tsaneva, I.R., B. Muller, S.C. West 1992. ATP-dependent branch migration of Holliday junctions promoted by the RuvA and RuvB proteins of E.coli. Cell 69:1171-1180
- Tsaneva, I.R., B. Muller, S.C. West 1993. RuvA and RuvB proteins of Escherichia coli exhibit DNA helicase activity in vitro. Proc.Natl.Acad.Sci.USA 90:1315-1319
- Parsons, C.A., A. Stasiak, S.C. West 1995. The E.coli RuvAB proteins branch migrate Holliday junctions through heterologous DNA sequences in a reaction facilitated by SSB. EMBO J. 14:5736-5744
- Hiom, K., S.C. West 1995. Characterisation of RuvAB-Holliday junction complexes by glycerol gradient sedimentation. Nucleic Acids Res. 23:3621-0
- West, S.C. 1996. The RuvABC proteins and Holliday junction processing in Escherichia coli. J.Bacteriol. 178:1237-1241
- Adams, D.E., S.C. West 1996. Bypass of DNA heterologies during RuvAB-mediated three- and four-strand branch migration. J.Mol.Biol. 263:582-596
- Foster, P.L., J.M. Trimarchi, R.A. Maurer 1996. Two enzymes, both of which process recombination intermediates, have opposite effects on adaptive mutation in Escherichia coli. Genetics 142:25-37
- Seigneur, M., V. Bidnenko, S.D. Ehrlich, B. Michel 1998. RuvAB acts at arrested replication forks. Cell 95:419-430
- Zahradka, K., D. Zahradka, M. Petranovic 2001. Loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli: the role of host genes ruvA, ruvB, ruvC, and recG. Res.Microbiol. 152:873-881