Site mutM
- Name: mutM
- Type: Gene
- Synonyms
b3635 MG1655 locus tag fpg - Mnemonic: Mutator
- Left End Point: 82.08
- Right End Point: 82.10
- Products:
formamidopyrimidine-DNA glycosylase 1,6-diaminoo-4-hydroxy-5-N-methyl-formamidopyrimidine-DNA glycosylase Fapy-DNA glycosylase - Direction: <
- Properties:
Property Comment repair system gene NULL - Priority: 1
- 4 Alleles of This Gene
mutM102::kan mutM103::mini-Tn10 mutM744(del)::kan mutM793-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10329 EcoliWiki mutM - Comment:
- High rate of G.C--T.A transversions. Selectable phenotype. Streptomycin resistance; azaserine resistance; chemostat growth.
- References:
- Siegel, E., V. Bryson 1967. Mutator gene of Escherichia coli. J.Bacteriol. 94:38-47
- Helling, R.B. 1968. Selection of a mutant of Escherichia coli which has high mutation rates. J.Bacteriol. 96:975-980
- Cox, E.C., T. Gibson 1974. Selection for high mutation rates in chemostats. Genetics 77:169-184
- Boiteux, S., T.R. O'Connor, J. Laval 1987. Formamidopyrimidine-DNA glycosylase (fpg) mutant of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein. EMBO J. 6:3177-3183
- Cabrera, M., Y. Nghiem, J.H. Miller 1988. mutM, a second mutator locus in Escherichia coli that generates G.C----T.A transversions. J.Bacteriol. 170:5405-5407
- Boiteux, S., O. Huisman 1989. Isolation of a formamidopyrimidine-DNA glycosylase (fpg) mutant of Escherichia coli K12. Mol.Gen.Genet. 215:300-305
- Coleman, S.H., D.G. Wild 1991. Location of the fpg gene on the Escherichia coli chromosome. Nucleic Acids Res. 19:3999
- Felzenszwalb, I., S. Boiteux, J. Laval 1992. Molecular cloning and DNA sequencing of the radC gene of Escherichia coli K-12. Mutat.Res. 273:263-269
- Graves, R.J., I. Felzenszwalb, J. Laval, T.R. O'Connor 1992. Excision of 5'-terminal deoxyribose phosphate from damaged DNA is catalyzed by the Fpg protein of Escherichia coli. J.Biol.Chem. 267:14429-14435
- Burland, V.D., G. Plunkett, D.L. Daniels, F.R. Blattner 1993. DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication. Genomics 16:551-561
- Sofia, H.J., V.D. Burland, D.L. Daniels, G. Plunkett, F.R. Blattner 1994. Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes. Nucleic Acids Res. 22:2576-2586
- Roldan-Arjona, T., B. Sedgwick 1996. DNA base damage induced by ionizing radiation recognized by Escherichia coli UvrABC nuclease but not Nth or Fpg proteins. Mol. Carcinog. 16:188-196
- Laval, J. 1996. Role of DNA repair enzymes in the cellular resistance to oxidative stress. Pathol.Biol.(Paris) 44:14-24
- Galhardo, R.S., C.E. Almeida, A.C. Leitao, J.B. Cabral-Neto 2000. Repair of DNA lesions induced by hydrogen peroxide in the presence of iron chelators in Escherichia coli: participation of endonuclease IV and Fpg. J.Bacteriol. 182:1964-1968