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Site uvrB
- Name: uvrB
- Type: Gene
- Synonyms
b0779 MG1655 locus tag dar-1 dar-6 - Mnemonic: Ultraviolet repair
- Left End Point: 17.52
- Right End Point: 17.56
- Products:
excision nuclease - Direction: >
- Priority: 1
- 12 Alleles of This Gene
uvrB151 uvrB153 uvrB16 uvrB230 uvrB27 uvrB29 uvrB30 uvrB45 uvrB5 uvrB501 uvrB751(del)::kan uvrB792-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank X03678 NCBI/GenBank X03722 EcoGene.org EG11062 EcoliWiki uvrB - Comment:
- Encodes an ATPase with one binding site that is structurally related to that of helicases. Part of an excision repair system along with uvrA and uvrC that removes a lesion in an ATP-dependent manner.
- References:
- Pannekoek, H., I. Noordermeer, P. Van de Putte 1979. Expression of the cloned uvrB gene of Escherichia coli: mode of transcription and orientation. J.Bacteriol. 139:54-63
- Sancar, A, ND Clarke, J Griswold, WJ Kennedy, WD Rupp 1981. Identification of the uvrB gene product. J. Mol. Biol. 148(1):63-76.
- van den Berg, E., J. Zwetsloot, I. Noordermeer, H. Pannekoeck, B. Dekker, R. Dijkema, H. van Ormondt 1981. The structure and function of the regulatory element of the Escherichia coli uvrB gene. Nucleic Acids Res. 9:5623-5643
- Fogliano, M., P.F. Schendel 1981. Evidence for the inducibility of the uvrB operon. Nature 289:196-198
- Sancar, G.B., A. Sancar, J.W. Little, W.D. Rupp 1982. The uvrB gene of Escherichia coli has both lexA-repressed and lexA-independent promoter. Cell 28:523-530
- Szybalski, E.H., W. Szybalski 1982. A physical map of the Escherichia coli bio operon. Gene 19:93-103
- Sancar, A., W.D. Rupp 1983. A novel repair enzyme UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region. Cell 33:249-260
- Backendorf, C., H. Spaink, A.P. Barbiero, P. Van de Putte 1986. Structure of the uvrB gene of Escherichia coli. Homology with other DNA repair enzymes and characterization of the uvrB5 mutation. Nucleic Acids Res. 14:2877-2890
- Arikan, E., M.S. Kulkarni, D.C. Thomas, A. Sancar 1986. Sequences of the E. coli uvrB gene and protein. Nucleic Acids Res. 14:2637-2650
- Tomer, G., O. Cohen-Fix, M.A. O'Donnell, M. Goodman, Z. Livneh 1996. Reconstitution of repair-gap UV mutagenesis with purified proteins from Escherichia coli: a role for DNA polymerases III and II. Proc.Natl.Acad.Sci.USA 93:1376-1380
- Sancar, A. 1996. DNA excision repair. Annu.Rev.Biochem. 65:43-81
- Moolenaar, G.F., K.L. Franken, P. van de Putte, N. Goosen 1997. Function of the homologous regions of the Escherichia coli DNA excision repair proteins UvrB and UvrC in stabilization of the UvrBC-DNA complex and in 3'-incision. Mutat.Res. 385:195-203
- Moolenaar, G.F., V. Monaco, G.A. van der Marel, J.H. van Boom, R. Visse, N. Goosen 2000. The effect of the DNA flanking the lesion on formation of the UvrB-DNA preincision complex.Mechanism for the UvrA-mediated loading of UvrB onto a DNA damaged site.
- Goosen, N., G.F. Moolenaar 2001. Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair. Res.Microbiol. 152:401-409