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Site rpoA
- Name: rpoA
- Type: Gene
- Synonyms
b3295 MG1655 locus tag phs Zilberstein et al. sez suppressor of envZ - Mnemonic: RNA polymerase
- Left End Point: 74.10
- Right End Point: 74.12
- Products:
RNA polymerase, alpha subunit - Direction: <
- Priority: 1
- 1 Alleles of This Gene
rpoA112(ts) - External Database Links:
Host Site Page Links EcoGene.org EG10893 EcoliWiki rpoA - Comment:
- Selectable phenotype. Phage P2 vir1 resistance. Alpha subunit is contact site for transcriptional activator proteins and promoter UP element. Key role in assembly of the core enz.
- References:
- Sunshine, M., B. Sauer 1975. A bacterial mutation blocking P2 phage late gene expression. Proc.Natl.Acad.Sci.USA 72:2770-2774
- Ovchinnikov, Y.A., V.M. Lipkin, N.N. Modyanov, O.Y. Chertov, Y.V. Smirnov 1977. Primary structure of alpha-subunit of DNA-dependent RNA polymerase from Escherichia coli. FEBS Lett. 76:108-111
- Post, L., M. Nomura 1979. Nucleotide sequence of the intercistronic region preceding the gene for RNA polymerase subunit a in Escherichia coli. J.Biol.Chem. 254:10604-10606
- Post, L., A.E. Arfsten, G.R. Davis, M. Nomura 1980. DNA sequence of the promoter region for the a ribosomal protein operon in Escherichia coli. J.Biol.Chem. 255:4653-4659
- Zilberstein, A., V. Agmon, S. Schuldiner, E. Padan 1982. The sodium/proton antiporter is part of the pH homeostasis mechanism in Escherichia coli. J.Biol.Chem. 257:3687-3691
- Cerretti, D.P., D. Dean, G.R. Davis, D.M. Bedwell, M. Nomura 1983. The spc ribosomal protein operon of Escherichia coli: sequence and cotranscription of the ribosomal protein genes and a protein export gene. Nucleic Acids Res. 11:2599-2616
- Rowland, G.C., P.M. Giffard, I.R. Booth 1984. Genetic studies of the phs locus of Escherichia coli, a mutation causing pleiotropic lesions in metabolism and pH homeostasis. FEBS Lett. 173:295-300
- Meek, D.W., R.S. Hayward 1984. Nucleotide sequence of the rpoA-rplQ DNA of Escherichia coli: a second regulatory binding site for protein S4?. Nucleic Acids Res. 12:5813-5821
- Bedwell, D.M., G.R. Davis, M. Gosink, L. Post, M. Nomura, H. Kestler, J.M. Zengel, L. Lindahl 1985. Nucleotide sequence of the alpha ribosomal protein operon of Escherichia coli. Nucleic Acids Res. 13:3891-3903
- Rowland, G.C., P.M. Giffard, I.R. Booth 1985. phs locus of Escherichia coli, a mutation causing pleiotropic lesions in metabolism, is an rpoA allele. J.Bacteriol. 164:972-975
- Giffard, P.M., I.R. Booth 1988. The rpoA341 allele of Escherichia coli specifically impairs the transcription of a group of positively-regulated operons. Mol.Gen.Genet. 214:148-152
- Kimura, M., A. Ishihama 1995. Functional map of the alpha subunit of Escherichia coli RNA polymerase: amino acid substitution within the amino-terminal assembly domain. J.Mol.Biol. 254:342-349
- Noel, R.J., W.S. Reznikoff 2000. Structural studies of lacUV5-RNA polymerase interactions in vitro.Ethylation interference and missing nucleoside analysis. J.Biol.Chem. 275:7708-7712