Site soxS
- Name: soxS
- Type: Gene
- Synonyms
b4062 MG1655 locus tag - Mnemonic: superoxide
- Left End Point: 92.14
- Right End Point: 92.15
- Products:
SoxR - Direction: <
- Properties:
Property Comment regulatory gene NULL - Priority: 0
- 1 Alleles of This Gene
soxS756(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10958 EcoliWiki soxS - Comment:
- Close to uvrAm, ssb. Homol. with C-term regions of AraC (pos.regul.)family regul.prots. and RhaS, RhaR pos. regulators,most similar to Tn10-encoded TetD. This family= DNA-binding prots, Biofilm-ind.
- References:
- Amabile-Cuevas, C.F., B. Demple 1991. Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon. Nucleic Acids Res. 19:4479-4484
- Wu, J., B. Weiss 1991. Two divergently transcribed genes, soxR and soxS, control a superoxide response regulon of Escherichia coli. J.Bacteriol. 173:2864-2871
- Wu, J., B. Weiss 1992. Two-stage induction of the soxRS (superoxide response) regulon of Escherichia coli. J.Bacteriol. 174:3915-3920
- Nunoshiba, T., E. Hidalgo, C. Amabile Cuevas, B. Demple 1992. Two-stage control of an oxidative stress regulon: the Escherichia coli SoxR protein triggers redox-inducible expression of the soxS regulatory gene. J.Bacteriol. 174:6054-6060
- Nunoshiba, T., E. Hidalgo, Z.-W. Li, B. Demple 1993. Negative autoregulation by the Escherichia coli SoxS protein: a dampening mechanism for the soxRS redox stress response. J.Bacteriol. 175:7492-7494
- Li, Z., B. Demple 1994. SoxS, an activator of superoxide stress genes in Escherichia coli.Purification and interaction with DNA. J.Biol.Chem. 269:18371-18377
- Fawcett, W.P., R.E. Wolf 1995. Genetic definition of the Escherichia coli zwf "Soxbox," the DNA binding site for SoxS-mediated induction of glucose 6-phosphate dehydrogenase in response to superoxide. J.Bacteriol. 177:1742-1750
- Jair, K.W., W.P. Fawcett, N. Fujita, A. Ishihama, A. Ishihama 1996. Ambidextrous transcriptional activation by SoxS: requirement for the C-terminal domain of the RNA polymerase alpha subunit in a subset of Escherichia coli superoxide-inducible genes. M
- Demple, B., E. Hidalgo, H. Ding 1999. Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response. Biochem Soc Symp 64:119-128
- Zheng, M., B. Doan, T.D. Schneider, G. Storz 1999. OxyR and SoxRS regulation of fur. J.Bacteriol. 181:4639-4643
- Griffith, K.L., R.E. Wolf 2001. Systematic mutagenesis of the DNA binding sites for SoxS in the Escherichia coli zwf and fpr promoters: identifying nucleotides required for DNA binding and transcription activation. Molecular Microbiology 40:1141-1154
- Fuentes, A.M., J.J. Diaz-Mejia, R. Maldonado-Rodriguez, C.F. Amabile-Cuevas 2001. Differential activities of the SoxR protein of Escherichia coli: SoxS is not required for gene activation under iron deprivation. FEMS Microbiol.Lett. 201:271-275
- Paterson, E.S., S.E. Boucher, I.B. Lambert 2002. Regulation of the nfsA Gene in Escherichia coli by SoxS. J.Bacteriol. 184:51-58
- Griffith, K.L., I.M. Shah, T.E. Myers, M.C. O'Neill, R.E. Wolf 2002. Evidence for "pre-recruitment" as a new mechanism of transcription activation in Escherichia coli: the large excess of SoxS binding sites per cell relative to the number of SoxS molec
- Ren, D., L.A. Bedzyk, S.M. Thomas, R.W. Ye, T.K. Wood 2004. Gene expression in Escherichia coli biofilms. Appl Microbiol Biotechnol 64:515-524