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Site vsr
- Name: vsr
- Type: Gene
- Synonyms
b1960 MG1655 locus tag - Mnemonic: very short (patch) repair
- Left End Point: 43.72
- Right End Point: 43.73
- Products:
Vsr endonuclease - Direction: <
- Properties:
Property Comment repair system gene NULL - Priority: 0
- 2 Alleles of This Gene
vsr-734(del)::kan vsr-834(del)::FRT - External Database Links:
Host Site Page Links EcoGene.org EG11068 EcoliWiki vsr - Comment:
- shares common promoter with dcm; 5' of coding region overlaps 3' of dcm, but not in frame. minimizes effects of C methylation.
- References:
- Bhagwat, A.S., A. Sohail, M. Lieb 1988. A new gene involved in mismatch correction in mismatch correction in Escherichia coli. Gene 74:155-156
- Sohail, A., M. Lieb, M. Dar, A.S. Bhagwat 1990. A gene required for very short patch repair in Escherichia coli is adjacent to the DNA cytosine methylase gene. J.Bacteriol. 172:4214-4221
- Hennecke, F., H. Kolmar, K. Brundl, H.J. Fritz 1991. The vsr gene product of E.coli K-12 is a strand- and sequence-specific DNA mismatch endonuclease. Nature 353:776-778
- Lieb, M. 1991. Spontaneous mutation at a 5-methylcytosine hotspot is prevented by very short patch VSP mismatch repair. Genetics 128:23-28
- Lieb, M., S. Rehmat 1995. Very short patch repair of T:G mismatches in vivo: importance of context and accessory proteins. J.Bacteriol. 177:660-666
- Macintyre, G., K.M. Doiron, C.G. Cupples 1997. The Vsr endonuclease of Escherichia coli: an efficient DNA repair enzyme and a potent mutagen. J.Bacteriol. 179:6048-6052
- Foster, P.L., W.A. Rosche 1998. Levels of the Vsr endonuclease do not regulate stationary-phase reversion of a lac- frameshift allele in Escherichia coli. J.Bacteriol. 180:1944-1946
- Gonzalez-Nicieza, R., D.P. Turner, B.A. Connolly 2001. DNA binding and cleavage selectivity of the Escherichia coli DNA G:T-mismatch endonuclease (vsr protein). J.Mol.Biol. 310:501-508