Site nhaB
- Name: nhaB
- Type: Gene
- Synonyms
b1186 MG1655 locus tag - Mnemonic: Na+ H+ antiporter; old ant=antiporter
- Left End Point: 26.57
- Right End Point: 26.60
- Products:
Na+/H+ antiporter - Direction: <
- Priority: 0
- 2 Alleles of This Gene
nhaB3(del)::Cm nhaB775(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG11392 EcoliWiki nhaB - Comment:
- regulator of intracellular pH. NhaB functions at pH below 8.
- References:
- Padan, E., N. Maisler, D. Taglicht, R. Karpel, S. Schuldiner 1989. Deletion of ant in Escherichia coli reveals its function in adaptation to high salinity and an alternative Na+/H+ antiporter systems(s). J.Biol.Chem. 264:20297-20302
- Thelen, P., T. Tsuchiya, E.B. Goldberg 1991. Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli. J.Bacteriol. 173:6553-6557
- Ohyama, T., R. Imaizumi, K. Igarashi, H. Kobayashi 1992. Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH. J.Bacteriol. 174:7743-7749
- Kayahara, T., P. Thelen, W. Ogawa, K. Inaba, M. Tsuda, E.B. Goldberg, T. Tsuchiya 1992. Properties of recombinant cells capable of growing on serine without NhaB Na+/H+ antiporter in Escherichia coli. J.Bacteriol. 174:7482-7485
- Pinner, E., E. Padan, S. Schuldiner 1992. Cloning, sequencing, and expression of the nhaB gene, encoding a Na+/H+ antiporter in Escherichia coli. J.Biol.Chem. 267:11064-11068
- Padan, E., S. Schuldiner 1993. Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells. J.Bioenerg.Biomembr. 25:647-669
- Pinner, E., Y. Kotler, E. Padan, S. Schuldiner 1993. Physiological role of nhaB, a specific Na+/H+ antiporter in Escherichia coli. J.Biol.Chem. 268:1729-1734
- Verkhovskaya, M.L., M.I. Verkhovsky, M. Wikstrom 1996. The respiration-driven active sodium transport system in E.coli does not function with lithium. FEBS Lett. 388:217-218
- Sakuma, T., N. Yamada, H. Saito, T. Kakegawa, H. Kobayashi 1998. pH dependence of the function of sodium ion extrusion systems in Escherichia coli. Biochim.Biophys.Acta 1363:231-237