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Site ppiA
- Name: ppiA
- Type: Gene
- Synonyms
b3363 MG1655 locus tag rotA by Leu and Walsh, for rotamase - Mnemonic: peptidylprolyl isomerase
- Left End Point: 75.21
- Right End Point: 75.23
- Products:
peptidylprolyl-cis-trans-isomerase A PPIase rotamase cyclophilin A? - Direction: <
- Priority: 0
- 1 Alleles of This Gene
ppiA771(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10757 EcoliWiki ppiA - Comment:
- a rotamase, periplasmic, in vivo role in protein folding is unknown.
- References:
- Liu, J., C.T. Walsh 1990. Peptidyl-prolyl cis-trans isomerase from Escherichia coli: a periplasmic homolog of cyclophilin that is not inhibited by cyclosporin A. Proc.Natl.Acad.Sci.USA 87:4028-4032
- Hayano, T., N. Takahashi, S. Kato, N. Maki, M. Suzuki 1991. Two distinct forms of peptidylprolyl-cis-trans-isomerase are expressed separately in periplasmic and cytoplasmic compartments of Escherichia coli cells. Biochemistry 30:3041-3048
- Schonbrunner, E.R., F.X. Schmid 1992. Peptidyl-prolyl cis-trans isomerase improves the efficiency of protein disulfide isomerase as a catalyst of protein folding. Proc.Natl.Acad.Sci.USA 89:4510-4513
- Norregaard-Madsen, M., B. Mygind, R. Pedersen, P. Valentin-Hansen, L. Sogaard-Andersen 1994. The gene encoding the periplasmic cyclophilin homologue, PPIase A, in Escherichia coli, is expressed from four promoters, three of which are activated by the c
- Kleerebezem, M., M. Heutink, J. Tommassen 1995. Characterization of an Escherichia coli rotA mutant, affected in periplasmic peptidyl-prolyl cis/trans isomerase. Mol.Microbiol. 18:313-320