Site nusG
- Name: nusG
- Type: Gene
- Synonyms
b3982 MG1655 locus tag - Mnemonic: Nu (lambda protein) survival
- Left End Point: 90.00
- Right End Point: 90.01
- Products:
NusG transcription termination (Rho-dependent) factor - Direction: >
- Priority: 0
- External Database Links:
Host Site Page Links EcoGene.org EG10667 EcoliWiki nusG - Comment:
- stabilizes the (Lambda)N-NusA-RNAP antitermination complex (which allows read-through of downstream terminators present in early operons of Lambda). Stimulates transcription elongation rates.
- References:
- Sullivan, S.L., M.E. Gottesman 1991. Requirement for E. coli NusG protein in factor-dependent transcription termination. Cell 58:989-994
- Das, A. 1992. How the phage Lambda N gene product suppresses transciption termination: communication of RNA polymerase with regulatory proteins mediated by signals in nascent RNA. J.Bacteriol. 174:6711-6716
- Linn, T., J. Greenblatt 1992. The NusA and NusG proteins of Escherichia coli increase the in vitro readthrough frequency of a transcriptional attenuator preceding the gene for the beta subunit of RNA polymerase. J.Biol.Chem. 267:1449-1454
- Li, J., R. Horwitz, S. McCracken, J. Greenblatt 1992. NusG, a new Escherichia coli elongation factor involved in transcriptional antitermination by the N protein of phage lambda. J.Biol.Chem. 267:6012-6019
- Li, J., S.W. Mason, J. Greenblatt 1993. Elongation factor NusG interacts with termination factor rho to regulate termination and antitermination of transcription. Genes Dev. 7:161-172
- Chow, J., P.P. Dennis 1994. Coupling between mRNA synthesis and mRNA stability in Escherichia coli. Mol.Microbiol. 11:919-931
- Burova, E., S.C. Hung, V. Sagitov, B.L. Stitt, M.E. Gottesman 1995. Escherichia coli NusG protein stimulates transcription elongation rates in vivo and in vitro. J.Bacteriol. 177:1388-1392
- Estevenon, A.M., M. Lemonnier, C. Rouquette, D. Lane 1997. Genetic basis of the MbrC "ploidy" phenotype in Escherichia coli. Mol.Gen.Genet. 256:291-297