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Site ffh
- Name: ffh
- Type: Gene
- Synonyms
b2610 MG1655 locus tag - Mnemonic: 54 kDa homolog
- Left End Point: 59.16
- Right End Point: 59.19
- Products:
4.5S-RNP protein 45 kD protein component of bacterial SRP - Direction: <
- Properties:
Property Comment GTP-binding protein NULL - Priority: 0
- External Database Links:
Host Site Page Links EcoGene.org EG10300 EcoliWiki ffh - Comment:
- protein-targeting mammalian counterpart: SRP (Signal recognition particle). particle includes 4.5S rRNA
- References:
- Poritz, M.A., H.D. Bernstein, K. Strub, D. Zopf, H. Wilhelm, P. Walter 1990. An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle. Science 250:1111-1117
- Phillips, G.J., T.J. Silhavy 1992. The E. coli ffh gene is necessary for viability and efficient protein export. Nature 359:744-746
- Bernstein, H.D., D. Zopf, D.M. Freymann, P. Walter 1993. Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog. Proc.Natl.Acad.Sci.USA 90:5229-5233
- Macfarlane, J., M. Muller 1995. The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle. Eur.J.Biochem. 233:766-771
- Powers, T., P. Walter 1995. Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases. Science 269:1422-1424
- Persson, B.C., G.O. Bylund, D.E. Berg, P.M. Wikstrom 1995. Functional analysis of the ffh-trmD region of the Escherichia coli chromosome by using reverse genetics. J.Bacteriol. 177:5554-5560
- Batey, R.T., M.B. Sagar, J.A. Doudna 2001. Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle. J.Mol.Biol. 307:229-246
- Park, S.K., F. Jiang, R.E. Dalbey, G.J. Phillips 2002. Functional analysis of the signal recognition particle in Escherichia coli by characterization of a temperature-sensitive ffh mutant. J.Bacteriol. 184:2642-2653
- Tian, H., J. Beckwith 2002. Genetic screen yields mutations in genes encoding all known components of the Escherichia coli signal recognition particle pathway. J.Bacteriol. 184:111-118