Site murA
- Name: murA
- Type: Gene
- Synonyms
b3189 MG1655 locus tag mrbA murZ - Mnemonic: Murein
- Left End Point: 71.84
- Right End Point: 71.87
- Products:
UDP-N-acetylglucosamine enolpyruvyl transferase UDP-N-acetylglucoamine 1-carboxyvinyltransferase - Direction: <
- Priority: 0
- 1 Alleles of This Gene
murA791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG11358 EcoliWiki murA - Comment:
- Selectable phenotype. phosphomycin resistance. SINGLE LOCUS FOR THIS ENZYME, not a murZ and murA.homologous to EPSP synthase, another enoylpyruvyl transfer enzyme.
- References:
- Venkateswaran, P.S., H.C. Wu 1972. Isolation and characterization of a phosphonomycin-resistant mutant of Escherichia coli K-12. J.Bacteriol. 110:935-944
- Marquardt, J.L., D.A. Siegele, R. Kolter, C.T. Walsh 1992. Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase. J.Bacteriol. 174:5748-5752
- Pucci, M.J., L.F. Discotto, T.J. Dougherty 1992. Cloning and identification of the Escherichia coli murB DNA sequence, which encodes UDP-N-acetylenolpyruvoylglucosamine reductase. J.Bacteriol. 174:1690-1693
- Brown, E.D., E.I. Vivas, C.T. Walsh, R. Kolter 1995. MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli. J.Bacteriol. 177:4194-4197
- Baum, E.Z., D.A. Montenegro, L. Licata, I. Turchi, G.C. Webb, B.D. Foleno, K. Bush 2001. Identification and characterization new inhibitors the Escherichia coli MurA enzyme. Antimicrob.Agents Chemother. 45:3182-3188