Site umuC
- Name: umuC
- Type: Gene
- Synonyms
b1184 MG1655 locus tag uvm - Mnemonic: UV mutator
- Left End Point: 26.52
- Right End Point: 26.55
- Products:
UmuDC SS-DNA binding protein subunit DNA polymerase V Pol V - Direction: >
- Properties:
Property Comment SOS-related induced as part of SOS response lexA regulon NULL - Priority: 1
- 5 Alleles of This Gene
umuC104 umuC122::Tn5 umuC25 umuC36 umuC773(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank M10107 NCBI/GenBank M29542 EcoGene.org EG11056 EcoliWiki umuC - Comment:
- inducible mutagenesis; error-prone repair
- References:
- Elledge, S.J., G.C. Walker 1983. Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli. J.Mol.Biol. 164:175-192
- Shinagawa, H., T. Kato, T. Ise, K. Makino, A. Nakata 1983. Cloning and characterization of the umu operon responsible for inducible mutagenesis in Escherichia coli. Gene 23:167-174
- Perry, K.L., S.J. Elledge, B.B. Mitchell, L. Marsh, G.C. Walker 1985. umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. Proc.Natl.Acad.Sci.USA 82:4331-4335
- Marsh, L., G.C. Walker 1985. Cold sensitivity induced by overproduction of UmuDC in Escherichia coli. J.Bacteriol. 162:155-161
- Kitagawa, Y., E. Akaboshi, H. Shinagawa, T. Horii, H. Ogawa, T. Kato 1985. Structural analysis of the umu operon required for inducible mutagenesis in Escherichia coli. Proc.Natl.Acad.Sci.USA 82:4336-4340
- Woodgate, R., M. Rajagopalan, C. Lu, H. Echols 1989. UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD'. Proc.Natl.Acad.Sci.USA 86:7301-7305
- Donnelly, C.E., G.C. Walker 1992. Coexpression of UmuD' with UmuC suppresses the UV mutagenesis deficiency of groE mutants. J.Bacteriol. 174:3133-3139
- Woodgate, R. 1992. Construction of a umuDC operon substitution mutation in Escherichia coli. Mutat.Res. 281:221-225
- Frank, E.G., D.G. Ennis, M. Gonzalez, A.S. Levine, R. Woodgate 1996. Regulation of SOS mutagenesis by proteolysis. Proc.Natl.Acad.Sci.USA 93:10291-10296
- Koffel-Schwartz, N., F. Coin, X. Veaute, R.P. Fuchs 1996. Cellular strategies for accommodating replication-hindering adducts in DNA: control by the SOS response in Escherichia coli. Proc.Natl.Acad.Sci.USA 93:7805-7810