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Site ptsG
- Name: ptsG
- Type: Gene
- Synonyms
b1101 MG1655 locus tag car cat CR gptA umg - Mnemonic: phosphotransferase system
- Left End Point: 24.94
- Right End Point: 24.97
- Products:
glucosephosphotransferase enzyme II glucose transporter IIB, IIGlc, IICBglc - Direction: >
- Priority: 1
- 5 Alleles of This Gene
ptsG0 ptsG21 ptsG22 ptsG23 ptsG763(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank J02618 EcoGene.org EG10787 EcoliWiki ptsG - Comment:
- Selectable phenotype. Loss: L-sorbose resistance; growth on fructose + 2-deoxyglucose or on fructose + 3-deoxy-3-fluoroglucose; growth on lactose + mannitol + a-methylglucoside.
- References:
- Kornberg, H.L., J. Smith 1972. Genetic control of glucose uptake by Escherichia coli. FEBS Lett. 20:270-272
- Curtis, S.J., W. Epstein 1975. Phosphorylation of D-glucose in Escherichia coli mutants defective in glucosephosphotransferase, mannosephosphotransferase, and glucokinase. J.Bacteriol. 122:1189-1199
- Bourd, G., R.S. Erlagaeva, T.N. Bolshakova, V.N. Gershanovich 1975. Glucose catabolite repression in Escherichia coli K12 mutants defective in methyl-a-D-glucose transport. J.Biochem.(Tokyo) 53:419-427
- Slater, A.C., M.C. Jones-Mortimer, H.L. Kornberg 1981. L-sorbose phosphorylation in Escherichia coli K-12. Biochim.Biophys.Acta 646:365-367
- Erni, B., B. Zanolari 1986. Glucose-permease of the bacterial phosphotransferase system. Gene cloning, overproduction and amino acid sequence of enzyme II^Glc. J.Biol.Chem. 261:16398-16403
- Bouma, C.L., N.D. Meadow, E.W. Stover, S. Roseman 1987. II-BGlc, a glucose receptor of the bacterial phosphotransferase system: molecular cloning of ptsG and purification of the receptor from an overproducing strain of Escherichia coli. Proc.Natl.Acad.
- Ruijter, G.J., G. van Meurs, M.A. Verwey, P.W. Postma, K. van Dam 1992. Analysis of mutations that uncouple transport from phosphorylation in enzyme IIGlc of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system. J.Bacteriol. 174
- Buhr, A., G.A. Daniels, B. Erni 1992. The glucose transporter of Escherichia coli. Mutants with impaired translocation activity that retain phosphorylation activity. J.Biol.Chem. 267:3847-3851
- Kimata, K., H. Takahashi, T. Inada, P. Postma, H. Aiba 1997. cAMP receptor protein-cAMP plays a crucial role in glucose-lactose diauxie by activating the major glucose transporter gene in Escherichia coli. Proc.Natl.Acad.Sci.USA 94:12914-12919
- Zeppenfeld, T., C. Larisch, J.W. Lengeler, K. Jahreis 2000. Glucose transporter mutants of Escherichia coli K-12 with changes in substrate recognition of IICB(Glc) and induction behavior of the ptsG gene. J.Bacteriol. 182:4443-52
- Notley-McRobb, L., T. Ferenci 2000. Substrate specificity and signal transduction pathways in the glucose-specific enzyme II (EII(Glc)) component of the Escherichia coli phosphotransferase system. J.Bacteriol. 182:4437-42
- Kimata, K., Y. Tanaka, T. Inada, H. Aiba 2001. Expression of the glucose transporter gene, ptsG, is regulated at the mRNA degradation step in response to glycolytic flux in Escherichia coli. EMBO J. 20:3587-3595
- Shin, D., N. Cho, S. Heu, S. Ryu 2003. Selective regulation of ptsG expression by Fis.Formation of either activating or repressing nucleoprotein complex in response to glucose. J.Biol.Chem. 278:14776-14781