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Site mscL
- Name: mscL
- Type: Gene
- Synonyms
b3291 MG1655 locus tag - Mnemonic: mechanosensitive channel
- Left End Point: 74.06
- Right End Point: 74.07
- Products:
mechanosensitive channel gating protein cytoplasmic membrane channel protein, responsive to mechanical stress - Direction: >
- Priority: 0
- 1 Alleles of This Gene
mscL727(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG11180 EcoliWiki mscL - Comment:
- MscL is a channel that opens large pore in cytoplasmic membrane in response to mechanical stress.
- References:
- Sukharev, S.I., P. Blount, B. Martinac, F.R. Blattner, C. Kung 1994. A large-conductance mechanosensitive channel in E. coli encoded by mscL alone. Nature 368:265-268
- Sukharev, S.I., P. Blount, B. Martinac, H.R. Guy, C. Kung 1996. MscL: a mechanosensitive channel in Escherichia coli. Soc.Gen. Physiol. Ser. 51:133-141
- Blount, P., S.I. Sukharev, P.C. Moe, M.J. Schroeder, H.R. Guy, C. Kung 1996. Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli. EMBO J. 15:4798-4805
- Blount, P., S.I. Sukharev, M.J. Schroeder, S.K. Nagle, C. Kung 1996. Single residue substitutions that change the gating properties of a mechanosensitive channel in Escherichia coli. Proc.Natl.Acad.Sci.USA 93:11652-11657
- Sukharev, S.I., P. Blount, B. Martinac, C. Kung 1997. Mechanosensitive channels of Escherichia coli: the MscL gene, protein, and activities. Annu Rev Physiol 59:633-657