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Site acrB
- Name: acrB
- Type: Gene
- Synonyms
acrE Ma et al. b0462 MG1655 locus tag - Mnemonic: Acridine
- Left End Point: 10.36
- Right End Point: 10.43
- Products:
AcrAB efflux pump - Direction: <
- Priority: 0
- 2 Alleles of This Gene
acrB747(del)::kan acrB847(del)::FRT - External Database Links:
Host Site Page Links EcoGene.org EG11704 EcoliWiki acrB - Comment:
- AcrAB plays major role in multiple antibiotic resistance (mar)
- References:
- Ma, D., D.N. Cook, M. Alberti, N.G. Pon, H. Nikaido, J.E. Hearst 1993. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J.Bacteriol. 175:6299-6313
- Ma, D., D.N. Cook, M. Alberti, N.G. Pon, H. Nikaido, J.E. Hearst 1995. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol.Microbiol. 16:45-55
- Okusu, H., D. Ma, H. Nikaido 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J.Bacteriol. 178:306-308
- Fralick, J.A. 1996. Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J.Bacteriol. 178:5803-5805
- White, D.G., J.D. Goldman, B. Demple, S.B. Levy 1997. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. J.Bacteriol. 179:6122-6126
- Rand, J.D., S.G. Danby, D.L. Greenway, R.R. England 2002. Increased expression of the multidrug efflux genes acrAB occurs during slow growth of Escherichia coli. FEMS Microbiol.Lett. 207:91-95