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Site mutT
- Name: mutT
- Type: Gene
- Synonyms
b0099 MG1655 locus tag nudA Bessman et al. in studies of series of nudix hydrolases - Mnemonic: Mutator
- Left End Point: 2.39
- Right End Point: 2.40
- Products:
nucleoside diphosphate-X hydrolase MutT (NudA) nudix hydrolase MutT nucleoside triphosphate pyrophosphorylase - Direction: >
- Properties:
Property Comment member of nudix hydrolase = MutT family - Priority: 1
- 4 Alleles of This Gene
mutT1 mutT2 mutT790(del)::kan mutT794-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank X04831 EcoGene.org EG10626 EcoliWiki mutT - Comment:
- Selectable phenotype. Streptomycin resistance; azaserine resistance; chemostat growth.
- References:
- Siegel, E., V. Bryson 1967. Mutator gene of Escherichia coli. J.Bacteriol. 94:38-47
- Helling, R.B. 1968. Selection of a mutant of Escherichia coli which has high mutation rates. J.Bacteriol. 96:975-980
- Cox, E.C., T. Gibson 1974. Selection for high mutation rates in chemostats. Genetics 77:169-184
- Akiyama, M., T. Horiuchi, M. Sekiguchi 1987. Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that causes A:T to C:G transversion. Mol.Gen.Genet. 206:9-16
- Bhatnagar, S.K., M.J. Bessman 1988. Studies on the mutator gene, mutT, of Escherichia coli. Molecular cloning of the gene, purification of the gene product, and identification of a novel nucleoside triphosphatase. J.Biol.Chem. 263:8953-8957
- Bhatnagar, S.K., L.C. Bullions, G. Lew, M.J. Bessman 1990. Characterization of the defect in the Escherichia coli mutT1 mutator gene. J.Bacteriol. 172:2802-2803
- Bhatnagar, S.K., L.C. Bullions, M.J. Bessman 1991. Characterization of the mutT nucleoside triphosphatase of Escherichia coli. J.Biol.Chem. 266:9050-9054
- Maki, H., M. Sekiguchi 1992. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature 355:273-275
- Fowler, R.G., J.A. Erickson, R.J. Isbell 1994. Activity of the Escherichia coli mutT mutator allele in an anaerobic environment. J.Bacteriol. 176:7727-7729