Site hemA
- Name: hemA
- Type: Gene
- Synonyms
b1210 MG1655 locus tag - Mnemonic: Hemin
- Left End Point: 27.22
- Right End Point: 27.25
- Products:
glutamyl-tRNA reductase GTR reductase - Direction: >
- Priority: 1
- 4 Alleles of This Gene
hemA29(NOTinSC) hemA30 hemA41 hemA8 - External Database Links:
Host Site Page Links NCBI/GenBank M30785 EcoGene.org EG10427 EcoliWiki hemA - Comment:
- Selectable phenotype. Loss: neomycin resistance. See Ikemi et al. re second,minor path ,not C5 glu-tRNA dHase, controlled by hemA
- References:
- Sasarman, A., K.E. Sanderson, M. Surdeanu, S. Sonea 1970. Hemin-deficient mutants of Salmonella typhimurium. J.Bacteriol. 102:531-536
- Avissar, Y.J., S.I. Beale 1989. Identification of the enzymatic basis for delta-aminolevulinic acid auxotrophy in the hemA mutant of Escherichia coli. J.Bacteriol. 171:2919-2924
- Li, J.M., C.S. Russell, S.D. Cosloy 1989. Cloning and structure of the hem A gene of Escherichia coli K-12. Gene 82:209-217
- Verkamp, E., B.K. Chelm 1989. Isolation, nucleotide sequence, and preliminary characterization of the Escherichia coli K-12 hemA gene. J.Bacteriol. 171:4728-4735
- Drolet, M., L. Peloquin, Y. Echelard, L. Cousineau, A. Sasarman 1989. Isolation and nucleotide sequence of the hemA gene of Escherichia coli K12. Mol.Gen.Genet. 216:347-352
- Ikemi, M., K. Murakami, M. Hashimoto, Y. Murooka 1992. Cloning and characterization of genes involved in the biosynthesis of delta-aminolevulinic acid in Escherichia coli. Gene 121:127-132
- Post, D.A., B. Hove-Jensen, R.L. Switzer 1993. Characterization of the hemA-prs region of the Escherichia coli and Salmonella typhimurium chromosomes: identification of two open reading frames and implications for prs expression. J.Gen.Microbiol. 139:2
- Chen, W., C.S. Russell, Y. Murooka, S.D. Cosloy 1994. 5-aminolevulinic acid synthesis in Escherichia coli requires expression of hemA. J.Bacteriol. 176:2743-2746
- Chen, W., L. Wright, S. Li, S.D. Cosloy, C.S. Russell, S. Li 1996. Expression of glutamyl-tRNA reductase in Escherichia coli [published erratum appears in Biochim.Biophys.Acta 1998 Feb 11;1395(3):361]. Biochim.Biophys.Acta 1309:109-121
- Verderber, E., L.J. Lucast, J.A. Van Dehy, P. Cozart, J.B. Etter, E.A. Best 1997. Role of the hemA gene product and delta-aminolevulinic acid in regulation of Escherichia coli heme synthesis. J.Bacteriol. 179:4583-4590