E. coli Genetic Resources at Yale
CGSC, The Coli Genetic Stock Center

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Site ftsA

• Name: ftsA
• Type: Gene
  Synonyms

  b0094	MG1655 locus tag
  divA

  
  
• Mnemonic: filamentation temperature sensitivity
• Left End Point: 2.24
• Right End Point: 2.27
  Products:

  septum protein FtsA

  
  
• Direction: >
• Properties:

  Property	Comment
  affects cell division/growth	septation

  
  
• Priority: 1
  7 Alleles of This Gene

  ftsA12(ts)

  ftsA16(Am)

  ftsA1882(ts)

  ftsA2(ts)

  ftsA27(ts)

  ftsA3(ts)

  ftsA791-YFP(::cat)

  
  
• External Database Links:

  Host Site	Page Links
  NCBI/GenBank	K02668
  NCBI/GenBank	M10429
  EcoGene.org	EG10339
  EcoliWiki	ftsA

  
  
• Comment:
• References:
  • Lutkenhaus, J., H.C. Wu 1980. Determination of transcriptional units and gene products from the ftsA region of Escherichia coli. J.Bacteriol. 143:1281-1288
  
  
  • Lutkenhaus, J., H. Wolf-Watz, W.D. Donachie 1980. Organization of genes in the ftsA-envA region of the Escherichia coli genetic map and identification of a new fts locus (ftsZ). J.Bacteriol. 142:615-620
  
  
  • Sullivan, N.F., W.D. Donachie 1984. Overlapping functional units in a cell division gene cluster in Escherichia coli. J.Bacteriol. 158:1198-1201
  
  
  • Robinson, A., D.J. Kenan, G.F. Hatfull, N.F. Sullivan, R. Spiegelberg, W.D. Donachie 1984. DNA sequence and transcriptional organization of essential cell division genes ftsQ and ftsA of Escherichia coli: evidence for overlapping transcriptional units
  
  
  • Jones, C.A., I.B. Holland 1984. Inactivation of essential division genes, ftsA, ftsZ, suppresses mutations at sfiB, a locus mediating division inhibition during the SOS response in E. coli. EMBO J. 3:1181-1186
  
  
  • Yi, Q.-M., S. Rockenbach, J.E. Ward, J. Lutkenhaus 1985. Structure and expression of the cell-division genes ftsQ, ftsA and ftsZ. J.Mol.Biol. 184:399-412
  
  
  • Begg, K.J., W.D. Donachie 1985. Cell shape and division in Escherichia coli: experiments with shape and division mutants. J.Bacteriol. 163:615-622
  
  
  • Descoteaux, A., G.R. Drapeau 1987. Regulation of cell division in Escherichia coli K-12: probable interactions among proteins FtsQ, FtsA, and FtsZ. J.Bacteriol. 169:1938-1942
  
  
  • Masters, M., T. Paterson, A.G. Popplewell, T. Owen-Hughes, J.H. Pringle, K.J. Begg 1989. The effect of DnaA protein levels and the rate of initiation at oriC on transcription originating in the ftsQ and ftsA genes: in vivo experiments. Mol.Gen.Genet. 2
  
  
  • Aldea, M., T. Garrido, J. Pla, M. Vicente 1990. Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters. EMBO J. 9:3787-3794
  
  
  • Robinson, A.C., K.J. Begg, E. MacArthur 1991. Isolation and characterization of intragenic suppressors of an Escherichia coli ftsA mutation. Res.Microbiol. 142:623-631
  
  
  • Vinella, D., R. D'Ari 1995. Overview of controls in the Escherichia coli cell cycle. Bioessays 17:527-0
  
  
  • Ma, X., D.W. Ehrhardt, W. Margolin 1996. Colocalization of cell division proteins FtsZ and FtsA to cytoskeletal structures in living Escherichia coli cells by using green fluorescent protein. Proc.Natl.Acad.Sci.USA 93:12998-13003
  
  
  • Addinall, S.G., J. Lutkenhaus 1996. FtsA is localized to the septum in an FtsZ-dependent manner. J.Bacteriol. 178:7167-7172
  
  
  • Cam, K., G. Rome, H.M. Krisch, J.P. Bouche 1996. RNase E processing of essential cell division genes mRNA in Escherichia coli. Nucleic Acids Res. 24:3065-3070
  
  
  • Pichoff, S., J. Lutkenhaus 2002. Unique and overlapping roles for ZipA and FtsA in septal ring assembly in Escherichia coli. EMBO J. 21:685-693