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Site lpxD
- Name: lpxD
- Type: Gene
- Synonyms
b0179 MG1655 locus tag fir rif-backwards firA see Kelly et al., Dicker and Seetharam [fir=reversal of rif] hlpA skp ssc - Mnemonic: lipid A eXpression
- Left End Point: 4.33
- Right End Point: 4.35
- Products:
UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase - Direction: >
- Properties:
Property Comment essential gene NULL - Priority: 1
- 4 Alleles of This Gene
lpxD200(ts) lpxD201(ts) lpxD36(ts) lpxD792-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank X54797 EcoGene.org EG10316 EcoliWiki lpxD - Comment:
- suppresses rifR phenotype. See Hirvas and Aasland refs. firA = hlpA (both on '90 map) = skp. See skp vs.lpxD. see Schnaitman and Klena. See complete sequence
- References:
- Aasland, R.J., J. Coleman, A.L. Holck, C.L. Smith, C.R.H. Raetz, K. Kleppe 1988. Identity of the 17-kilodalton protein, a DNA-binding protein from Escherichia coli, and the firA gene product. J.Bacteriol. 170:5916-5918
- Coleman, J., C.R.H. Raetz 1988. First committed step of lipid A biosynthesis in Escherichia coli: sequence of the lpxA gene. J.Bacteriol. 170:1268-1274
- Hirvas, L., J. Coleman, P. Koski, M. Vaara 1990. Bacterial "histone-like protein I" (HLP-I) is an outer membrane constituent?. FEBS Lett. 262:123-126
- Hirvas, L., P. Koski, M. Vaara 1991. The ompH gene of Yersinia enterocolitica: cloning, sequencing, expression, and comparison with known enterobacterial ompH sequences. J.Bacteriol. 173:1223-1229
- Dicker, I.B., S. Seetharam 1991. Cloning and nucleotide sequence of the firA gene and the firA200(Ts) allele from Escherichia coli. J.Bacteriol. 173:334-344
- Vuorio, R., M. Vaara 1992. Mutants carrying conditionally lethal mutations in outer membrane genes omsA and firA (ssc) are phenotypically similar, and omsA is allelic to firA. J.Bacteriol. 174:7090-7097
- Helander, I.M., B. Lindner, U. Seydel, M. Vaara 1993. Defective biosynthesis of the lipid A component of temperature-sensitive firA (omsA) mutant of Escherichia coli. Eur.J.Biochem. 212:363-369
- Schnaitman, CA, JD Klena 1993. Genetics of lipopolysaccharide biosynthesis in enteric bacteria. Microbiol. Rev. 57(3):655-82.
- Kelly, T.M., S.A. Stachula, C.H.R. Raetz, M.S. Anderson 1993. The firA gene of Escherichia coli encodes UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase. The third step of endotoxin biosynthesis. J.Biol.Chem. 268:19866-19874
- Roy, A.M., J. Coleman 1994. Mutations in firA, encoding the second acyltransferase in lipopolysaccharide biosynthesis, affect multiple steps in lipopolysaccharide biosynthesis. J.Bacteriol. 176:1639-1646