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Site cpxA
- Name: cpxA
- Type: Gene
- Synonyms
b3911 MG1655 locus tag ecfB energy coupling factor, Thorbjarnardottir eup Plate, energy uncoupling phenotype ssd succinate-nonutilizing,hi-serine deaminase, Morris and Newman - Mnemonic: conjugative plasmid eXpression
- Left End Point: 88.40
- Right End Point: 88.43
- Products:
membrane sensor in two-component cpxAR signal transduction system inner membrane histidine kinase - Direction: <
- Properties:
Property Comment encodes membrane protein sensor in CpxAR signal transduction - Priority: 1
- 2 Alleles of This Gene
cpxA2(ts) cpxA771(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank M36795 NCBI/GenBank X13307 EcoGene.org EG10163 EcoliWiki cpxA - Comment:
- Selectable phenotype: Phage Q resistance. 2-compon.signal transd.syst.membr.sensor.Highly pleiotropic.KanR;growth on L-ser,gen'lized aminoglycoside resist.;energy coupling;adhesion,surf.sens'g,biofilm
- References:
- Thorbjarnardottir, S., R.A. Magnusdottir, G. Eggertsson 1978. Mutations determining generalized resistance to aminoglucoside antibiotics in Escherichia coli. Mol.Gen.Genet. 161:89-98
- McEwen, J., P. Silverman 1980. Genetic analysis of Escherichia coli K-12 chromosomal mutants defective in expression of F-plasmid functions: identification of genes cpxA and cpxB. J.Bacteriol. 144:60-67
- Silverman, P., K. Nat, J. McEwen, R. Birchman 1980. Selection of Escherichia coli K-12 mutants that prevent expression of F-plasmid functions. J.Bacteriol. 143:1519-1523
- Morris, J.F., E.B. Newman 1980. Map location of the ssd mutation in Escherichia coli. J.Bacteriol. 143:1504-1505
- McEwen, J., P. Silverman 1980. Chromosomal mutations of Escherichia coli that alter expression of conjugative plasmid functions. Proc.Natl.Acad.Sci.USA 77:513-517
- Newman, E.B., N. Malik, C. Walker 1982. L-Serine degradation in Escherichia coli K-12: directly isolated ssd mutants and their intragenic revertants. J.Bacteriol. 150:710-715
- Silverman, P.M. 1982. Gene cpxA is a new addition to the linkage map of Escherichia coli K-12. J.Bacteriol. 150:425-428
- Albin, R., P.M. Silverman 1984. Identification of the Escherichia coli K-12 cpxA locus as a single gene: construction and analysis of biologically-active cpxA gene fusions. Mol.Gen.Genet. 197:272-279
- Albin, R., P.M. Silverman 1984. Physical and genetic structure of the glpK-cpxA interval of the Escherichia coli K-12 chromosome. Mol.Gen.Genet. 197:261-271
- Albin, R., R. Weber, P.M. Silverman 1986. The Cpx proteins of Escherichia coli K-12. Immunologic detection of the chromosomal cpxA gene product. J.Biol.Chem. 261:4698-4705
- Plate, C.A.S., A. Seely, T.G. Laffler 1986. Evidence for a protonmotive force related regulatory system in Escherichia coli and its effects on lactose transport. Biochemistry 25:6127-6132
- Weber, R., P.M. Silverman 1988. The cpx proteins of Escherichia coli K12. Structure of the cpxA polypeptide as an inner membrane component. J.Mol.Biol. 203:467-478
- Iuchi, S., D. Furlong, E.C.C. Lin 1989. Differentiation of arcA, arcB, and cpxA mutant phenotypes of Escherichia coli by sex pilus formation and enzyme regulation. J.Bacteriol. 171:2889-2893
- Rainwater, S., P.M. Silverman 1990. The Cpx proteins of Escherichia coli K-12: evidence that cpxA, ecfB, ssd, and eup mutations all identify the same gene. J.Bacteriol. 172:2456-2461
- Silverman, P.M., L. Tran, R. Harris, H.M. Gaudin 1993. Accumulation of the F plasmid TraJ protein in cpx mutants of Escherichia coli. J.Bacteriol. 175:921-925
- Cosma, C.L., P.N. Danese, J.H. Carlson, T.J. Silhavy, W.B. Snyder 1995. Mutational activation of the Cpx signal transduction pathway of Escherichia coli suppresses the toxicity conferred by certain envelope-associated stresses. Mol.Microbiol. 18:491-50
- Raivio, T., T.J. Silhavy 1997. Transduction of envelope stress in Escherichia coli by the Cpx two-component system. J.Bacteriol. 179:7724-7733
- Otto, K., T.J. Silhavy 2002. Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway. Proc.Natl.Acad.Sci.USA 99:2287-2292