Site arnA
- Name: arnA
- Type: Gene
- Synonyms
b2255 MG1655 locus tag pmrI SAF yfbG - Mnemonic: ara4N (4-amino-4-deoxy-L-arabinose)
- Left End Point: 51.00
- Right End Point: 51.04
- Products:
Ara-4N lipid A modifying transformylase/decarboxylase enzyme UDP-ara4N formyltransferase/UDP-glucuronate deHase (bifctnl.) - Direction: >
- Properties:
Property Comment encodes bifunctional protein NULL - Priority: 0
- 2 Alleles of This Gene
arnA736(del)::kan arnA791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG14091 EcoliWiki arnA - Comment:
- In UDP-Ara-4N synthesis: first-step successive C4 oxidation and C6 deC'ns plus Ara-4N formyltransferase
- References:
- Gatzeva-Topalova, P.Z., A.P. May, M.C. Sousa 2004. Crystal structure of Escherichia coli ArnA (PmrI) decarboxylase domain.A key enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. Biochemistry 43:13370-13379
- Breazeale, S.D., A.A. Ribeiro, A.L. McClerren, C.R. Raetz 2005. A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose.Identification and function oF UDP-4-deoxy-4-form
- Gatzeva-Topalova, P.Z., A.P. May, M.C. Sousa 2005. Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain.An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. Biochemistry 44:5