Product - ATP:GTP 3'-pyrophosphotransferase

Product ATP:GTP 3'-pyrophosphotransferase

Product Names:

ATP:GTP 3'-pyrophosphotransferase

ppGpp synthetase

guanosine 3'5'-bispyrophosphate synthetase I

stringent factor

EC#: 2.7.6.5

Encoded By: relA

External Database Links:

Host Site	Page Links
EcoCyc	RELA-MONOMER

Comment:
required for synthesis of ppGpp during stringent response to a.a. starvation. decreased (p)ppGpp levels are produced by chloramphenicol, inhibiting peptidyl transferase, and cold temperatures.produces 3/5/bispyrophosphate under aa starv.

References:

Burkovski, A., B. Weil, R. Kramer 1995. Glutamate excretion in Escherichia coli: dependency on the relA and spoT genotype. Arch.Microbiol. 164:24-28
Gustavsson, N., A. Diez, T. Nystrom 2002. The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage. Mol.Microbiol. 43:107-117

E. coli Genetic Resources at Yale CGSC, The Coli Genetic Stock Center

Product ATP:GTP 3'-pyrophosphotransferase

E. coli Genetic Resources at Yale
CGSC, The Coli Genetic Stock Center