E. coli Genetic Resources at Yale
CGSC, The Coli Genetic Stock Center

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Site ampC

• Name: ampC
• Type: Gene
  Synonyms

  ampA
  b4150	MG1655 locus tag
  pbpC

  
  
• Mnemonic: Ampicillin
• Left End Point: 94.31
• Right End Point: 94.34
  Products:

  beta-lactamase, Type C, and PBP C

  
  
• Direction: <
• Priority: 1
  4 Alleles of This Gene

  ampC11

  ampC12

  ampC3

  ampC777(del)::kan

  
  
• External Database Links:

  Host Site	Page Links
  EcoGene.org	EG10040
  EcoliWiki	ampC

  
  
• Comment:
  • penicillin resistance. Selectable Pheno. Increased expression: ampicillin resistance; Duplication: ampicillin resistance. Affects cell morphology, peptidoglycan synth./metab.
• References:
  • Eriksson-Grennberg, K.G., H.G. Boman, J.A.T. Jansson, S. Thoren 1965. Resistance of Escherichia coli to penicillins. I. Genetic study of some ampicillin mutants. J.Bacteriol. 90:54-62
  
  
  • Normark, S., T. Edlund, T. Grundstrom, S. Bergstrom, H. Wolf-Watz 1977. Escherichia coli K-12 mutants hyperproducing chromosomal beta-lactamase by gene repetitions. J.Bacteriol. 132:912-922
  
  
  • Cole, S.T., J.R. Guest 1979. Production of a soluble form of fumarate reductase by multiple gene duplications in Escherichia coli K12. Eur.J.Biochem. 102:65-71
  
  
  • Edlund, T., T. Grundstrom, S. Normark 1979. Isolation and characterization of DNA repetitions carrying the chromosomal B-lactamase gene of Escherichia coli K-12. Mol.Gen.Genet. 173:115-125
  
  
  • Grundstrom, T., B. Jaurin, T. Edlund, S. Normark 1980. Physical mapping and expression of hybrid plasmids carrying chromosomal beta-lactamase genes of Escherichia coli K-12. J.Bacteriol. 143:1127-1134
  
  
  • Jaurin, B., T. Grundstrom 1981. ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamase of the penicillinase type. Proc.Natl.Acad.Sci.USA 78:4897-4901
  
  
  • Edlund, T., S. Normark 1981. Recombination between short DNA homologies causes tandem duplications. Nature 292:269-271
  
  
  • Jaurin, B., T. Grundstrom, T. Edlund, S. Normark 1981. The E. coli beta-lactamase attenuator mediates growth rate-dependent regulation. Nature 290:221-225
  
  
  • Grundstrom, T., B. Jaurin 1982. Overlap between ampC and frd operons on the Escherichia coli chromosome. Proc.Natl.Acad.Sci.USA 79:1111-1115
  
  
  • Jaurin, B., T. Grundstrom, S. Normark 1982. Sequence elements determining ampC promoter strength in E. coli. EMBO J. 1:875-881
  
  
  • Henderson, T.A., K.D. Young, S.A. Denome, P.K. Elf 1997. AmpC and AmpH, proteins related to the class C beta-lactamases, bind penicillin and contribute to the normal morphology of Escherichia coli. J.Bacteriol. 179:6112-6121