Site cfa
- Name: cfa
- Type: Gene
- Synonyms
b1661 MG1655 locus tag cdfA - Mnemonic: cyclopropane-fatty acid
- Left End Point: 37.49
- Right End Point: 37.52
- Products:
cyclopropane fatty acid synthase - Direction: >
- Priority: 1
- 7 Alleles of This Gene
cfa-0 cfa-1 cfa-2 cfa-3 cfa-4 cfa-5::kan cfa-739(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank M98330 EcoGene.org EG11531 EcoliWiki cfa - Comment:
- CFA formation in post-synthetic modification of the lipid bilayer at entry of stationary phase. see gene product description (adds methylene derived from methyl of SAM). Factor in acid resistance.
- References:
- Grogan, D.W., J.E. Cronan 1983. Use of lambda plasmids for deletion mapping of non-selectable markers cloned in plasmids. Gene 22:75-83
- Grogan, D.W., J.E. Cronan 1984. Genetic characterization of Escherichia coli cyclopropane fatty acid (cfa) locus and neighboring loci. Mol.Gen.Genet. 196:367-372
- Grogan, D.W., J.E. Cronan 1984. Cloning and manipulation of the Escherichia coli cyclopropane fatty acid synthase gene: physiological aspects of enzyme overproduction. J.Bacteriol. 158:286-295
- Wang, A.Y., D.W. Grogan, J.E. Cronan 1985. Cyclopropane fatty acid synthase of Escherichia coli: deduced amino acid sequence, purification, and studies of the enzyme active site. Biochemistry 31:11020-11028
- Grogan, D.W., J.E. Cronan 1986. Characterization of Escherichia coli mutants cmpletely defective in synthesis of cyclopropane fatty acids. J.Bacteriol. 166:872-877
- Grogan, D.W., J.E. Cronan 1997. Cyclopropane ring formation in membrane lipids of bacteria. Microbiol.Mol.Biol.Rev. 61:429-441
- Chang, Y.Y., J.E. Cronan 1999. Membrane cyclopropane fatty acid content is a major factor in acid resistance of Escherichia coli. Mol.Microbiol. 33:249-259