Site tag
- Name: tag
- Type: Gene
- Synonyms
b3549 MG1655 locus tag - Mnemonic: 3-methyl adenine glycosylase
- Left End Point: 79.99
- Right End Point: 80.00
- Products:
3-methyladenine DNA glycosylase I - Direction: >
- Properties:
Property Comment repair system gene protects from alkylation-induced cell death - Priority: 1
- 1 Alleles of This Gene
tag-733(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank J02606 EcoGene.org EG10986 EcoliWiki tag - Comment:
- constitutively expressed
- References:
- Karran, P., T. Lindahl, I. Ofsteng, G. Evensen, E. Seeberg 1980. Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase. J.Mol.Biol. 140:101-127
- Sedgwick, B. 1982. Genetic mapping of the ada and adc mutations affecting the adaptive response of Escherichia coli to alkylating agents. J.Bacteriol. 150:984-988
- Evensen, G., E. Seeberg 1982. Adaptation to alkylation resistance involves the induction of a DNA glycosylase. Nature 296:773-775
- Clarke, N.D., M. Kvaal, E. Seeberg 1984. Cloning of Escherichia coli genes encoding 3-methyladenine DNA glycosylases I and II. Mol.Gen.Genet. 197:368-372
- Steinum, A.L., E. Seeberg 1986. Nucleotide sequence of the tag gene from Escherichia coli. Nucleic Acids Res. 14:3763-3772
- Sakumi, K., Y. Nakabeppu, H. Yamamoto, S.I. Kawabata, S. Iwanaga, M. Sekiguchi 1986. Purification and structure of 3-methyladenine-DNA glycosylase I of Escherichia coli. J.Biol.Chem. 261:15761-15766
- Bjelland, S., E. Seeberg 1996. Different efficiencies of the Tag and AlkA DNA glycosylases from Escherichia coli in the removal of 3-methyladenine from single-stranded DNA. FEBS Lett. 397:127-129
- Salmelin, C., J. Vilpo 2002. Chlorambucil-induced high mutation rate and suicidal gene downregulation in a base excision repair-deficient Escherichia coli strain. Mutation Research 500:125-134