Site ftsZ
- Name: ftsZ
- Type: Gene
- Synonyms
b0095 MG1655 locus tag sfiB sulB suppressor of lon - Mnemonic: filamentation temperature sensitivity
- Left End Point: 2.27
- Right End Point: 2.30
- Products:
septum protein FtsZ, GTP-binding - Direction: >
- Properties:
Property Comment affects cell division/growth NULL GTP-binding protein NULL - Priority: 1
- 4 Alleles of This Gene
ftsZ103 ftsZ25(ts) ftsZ26(ts) ftsZ844(ts) - External Database Links:
Host Site Page Links EcoGene.org EG10347 EcoliWiki ftsZ - Comment:
- required for initiation of cell septation. cell div.starts with ring of GTP-binding protein FtsZ. Heat shock and SOS responses block cell div, but that can be overcome by excess FtsZ in some cases.
- References:
- Lutkenhaus, J.F. 1983. Coupling of DNA replication and cell division: sulB is an allele of ftsZ. J.Bacteriol. 154:1339-1346
- Jones, C.A., I.B. Holland 1984. Inactivation of essential division genes, ftsA, ftsZ, suppresses mutations at sfiB, a locus mediating division inhibition during the SOS response in E. coli. EMBO J. 3:1181-1186
- Sullivan, N.F., W.D. Donachie 1984. Overlapping functional units in a cell division gene cluster in Escherichia coli. J.Bacteriol. 158:1198-1201
- Begg, K.J., W.D. Donachie 1985. Cell shape and division in Escherichia coli: experiments with shape and division mutants. J.Bacteriol. 163:615-622
- Yi, Q.-M., S. Rockenbach, J.E. Ward, J. Lutkenhaus 1985. Structure and expression of the cell-division genes ftsQ, ftsA and ftsZ. J.Mol.Biol. 184:399-412
- Yi, Q.-M., J. Lutkenhaus 1985. The nucleotide sequence of the essential cell-division gene ftsZ of Escherichia coli. Gene 36:241-247
- Lutkenhaus, J., B. Sanjanwala, M. Lowe 1986. Overproduction of FtsZ suppresses sensitivity of lon mutants to division inhibition. J.Bacteriol. 166:756-762
- Jaffe, A., R. D'Ari, V.J. Norris 1986. SOS-independent coupling between DNA replication and cell division in Escherichia coli. J.Bacteriol. 165:66-71
- Descoteaux, A., G.R. Drapeau 1987. Regulation of cell division in Escherichia coli K-12: probable interactions among proteins FtsQ, FtsA, and FtsZ. J.Bacteriol. 169:1938-1942
- Jung, H.K., F. Ishino, M. Matsuhashi 1989. Inhibition of growth of ftsQ, ftsA, and ftsZ mutant cells of Escherichia coli by amplification of a chromosomal region encompassing closely aligned cell division and cell growth genes. J.Bacteriol. 171:6379-63
- Lutkenhaus, J. 1990. Regulation of cell division in E. coli. Trends Genet. 6:22-25
- Aldea, M., T. Garrido, J. Pla, M. Vicente 1990. Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters. EMBO J. 9:3787-3794
- Bi, E., J. Lutkenhaus 1990. FtsZ regulates frequency of cell division in Escherichia coli. J.Bacteriol. 172:2765-2768
- Dai, K., J. Lutkenhaus 1991. ftsZ is an essential cell division gene in Escherichia coli. J.Bacteriol. 173:3500-3506
- Pla, J., M. Sanchez, P. Palacios, M. Vicente, M. Aldea 1991. Preferential cytoplasmic location of FtsZ, a protein essential for Escherichia coli septation. Mol.Microbiol. 5:1681-1686
- RayChaudhuri, D., J.T. Park 1992. Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein. Nature 359:251-254
- Bi, E., J. Lutkenhaus 1992. Isolation and characterization of ftsZ alleles that affect septal morphology. J.Bacteriol. 174:5414-5423
- Garrido, T., M. Sanchez, P. Palacios, M. Aldea, M. Vicente 1993. Transcription of ftsZ oscillates during the cell cycle of Escherichia coli. EMBO J. 12:3957-3965
- Lutkenhaus, J. 1993. FtsZ ring in bacterial cytokinesis. Mol.Microbiol. 9:403-409
- Dai, K., A. Mukherjee, Y. Xu, J. Lutkenhaus 1994. Mutations in ftsZ that confer resistance to SulA affect the interaction of FtsZ with GTP. J.Bacteriol. 176:130-136
- Vinella, D., R. D'Ari 1995. Overview of controls in the Escherichia coli cell cycle. Bioessays 17:527-0
- Addinall, S.G., J. Lutkenhaus 1996. FtsA is localized to the septum in an FtsZ-dependent manner. J.Bacteriol. 178:7167-7172
- Cam, K., G. Rome, H.M. Krisch, J.P. Bouche 1996. RNase E processing of essential cell division genes mRNA in Escherichia coli. Nucleic Acids Res. 24:3065-3070
- Ma, X., D.W. Ehrhardt, W. Margolin 1996. Colocalization of cell division proteins FtsZ and FtsA to cytoskeletal structures in living Escherichia coli cells by using green fluorescent protein. Proc.Natl.Acad.Sci.USA 93:12998-13003
- Raskin, D.M., P.A. de Boer 1997. The MinE ring: an FtsZ-independent cell structure required for selection of the correct division site in E.coli. Cell 91:685-694
- Powell, B.S., D.L. Court 1998. Control of ftsZ expression, cell division, and glutamine metabolism in Luria-Bertani medium by the alarmone ppGpp in Escherichia coli. J.Bacteriol. 180:1053-1062
- Sun, Q., W. Margolin 1998. FtsZ dynamics during the division cycle of live Escherichia coli cells. J.Bacteriol. 180:2050-2056
- Mukherjee, A., C. Cao, J. Lutkenhaus 1998. Inhibition of FtsZ polymerization by SulA, an inhibitor of septation in Escherichia coli. Proc.Natl.Acad.Sci.USA 95:2885-2890
- Liu, G., K. Begg, A. Geddes, W.D. Donachie 2001. Transcription of essential cell division genes is linked to chromosome replication in Escherichia coli. Molecular Microbiology 40:909-916
- Stricker, J., P. Maddox, E.D. Salmon, H.P. Erickson 2002. Rapid assembly dynamics of the Escherichia coli FtsZ-ring demonstrated by fluorescence recovery after photobleaching. Proc.Natl.Acad.Sci.USA 99:3171-3175
- Hale, C.A., P.A. de Boer 2002. ZipA is required for recruitment of FtsK, FtsQ, FtsL, and FtsN to the septal ring in Escherichia coli. J.Bacteriol. 184:2552-2556
- Anderson, D.E., F.J. Gueiros-Filho, H.P. Erickson 2004. Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins. J.Bacteriol. 186:5775-5781
- Margalit, D.N., L. Romberg, R.B. Mets, A.M. Hebert, T.J. Mitchison, M.W. Kirschner, D. RayChaudhuri 2004. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality.[erratum appear
- Amos, L.A., F. van den Ent, J. Lowe 2004. Structural/functional homology between the bacterial and eukaryotic cytoskeletons. Curr Opin Cell Biol 16:24-31