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Site nhaA
- Name: nhaA
- Type: Gene
- Synonyms
ant pre-90 papers, antiporter b0019 MG1655 locus tag - Mnemonic: Na+ H+ antiporter; old ant=antiporter
- Left End Point: 0.38
- Right End Point: 0.40
- Products:
Na+/H+ antiporter - Direction: >
- Properties:
Property Comment stress response adaptation to high salinity and alkaline pH - Priority: 1
- 2 Alleles of This Gene
nhaA1(del)::kan nhaA737(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank J03879 EcoGene.org EG10652 EcoliWiki nhaA - Comment:
- may be distinct from the respiration driven active sodium transport (AST). NhaA/B also operates with Li+. Verkhovskaya et al. ref. NhaA is induced within wide range of medium pH
- References:
- Goldberg, E.B., T. Arbel, J. Chen, R. Karpel, G.A. Mackie, S. Schuldiner 1987. Characterization of a Na+/H+ antiporter gene of Escherichia coli. Proc.Natl.Acad.Sci.USA 84:2615-2619
- Karpel, R., Y. Olami, D. Taglicht, S. Schuldiner, E. Padan 1988. Sequencing of the gene ant which affects the Na+/H+ antiporter activity in Escherichia coli. J.Biol.Chem. 263:10408-10414
- Padan, E., N. Maisler, D. Taglicht, R. Karpel, S. Schuldiner 1989. Deletion of ant in Escherichia coli reveals its function in adaptation to high salinity and an alternative Na+/H+ antiporter systems(s). J.Biol.Chem. 264:20297-20302
- Thelen, P., T. Tsuchiya, E.B. Goldberg 1991. Characterization and mapping of a major Na+/H+ antiporter gene of Escherichia coli. J.Bacteriol. 173:6553-6557
- Karpel, R., T. Alon, G. Glaser, S. Schuldiner, E. Padan 1991. Expression of a sodium proton antiporter (NhaA) in Escherichia coli is induced by Na+ and Li+ ions. J.Biol.Chem. 266:21753-21759
- Taglicht, D., E. Padan, S. Schuldiner 1991. Overproduction and purification of a functional Na+/H+ antiporter coded by nhaA (ant) from Escherichia coli. J.Biol.Chem. 266:11289-11294
- Ohyama, T., R. Imaizumi, K. Igarashi, H. Kobayashi 1992. Escherichia coli is able to grow with negligible sodium ion extrusion activity at alkaline pH. J.Bacteriol. 174:7743-7749
- Rahav-Manor, O., O. Carmel, R. Karpel, D. Taglicht, G. Glaser, S. Schuldiner, E. Padan 1992. NhaR, a protein homologous to a family of bacterial regulatory proteins (LysR) regulates nhaA, the sodium proton antiporter gene in Escherichia coli. J.Biol.Ch
- Gerchman, Y., Y. Olami, A. Rimon, D. Taglicht, S. Schuldiner, E. Padan 1993. Histidine-226 is part of the pH sensor of NhaA, a Na+/H+ antiporter in Escherichia coli. Proc.Natl.Acad.Sci.USA 90:1212-1216
- Padan, E., S. Schuldiner 1993. Na+/H+ antiporters, molecular devices that couple the Na+ and H+ circulation in cells. J.Bioenerg.Biomembr. 25:647-669
- Inaba, K., T. Kuroda, T. Shimamoto, T. Kayahara, M. Tsuda, T. Tsuchiya 1994. Lithium toxicity and Na+(Li+)/H+ antiporter in Escherichia coli. Biol.Pharm.Bull. 17:395-398
- Dover, N., C.F. Higgins, O. Carmel, A. Rimon, E. Pinner, E. Padan 1996. Na+-induced transcription of nhaA, which encodes an Na+/H+ antiporter in Escherichia coli, is positively regulated by nhaR and affected by hns. J.Bacteriol. 178:6508-6517
- Verkhovskaya, M.L., M.I. Verkhovsky, M. Wikstrom 1996. The respiration-driven active sodium transport system in E.coli does not function with lithium. FEBS Lett. 388:217-218