Site soxR
- Name: soxR
- Type: Gene
- Synonyms
b4063 MG1655 locus tag - Mnemonic: superoxide
- Left End Point: 92.15
- Right End Point: 92.16
- Products:
SoxR transcriptional activator and sensor - Direction: >
- Properties:
Property Comment regulatory gene NULL superoxide stress regulon NULL - Priority: 0
- 6 Alleles of This Gene
soxR101(Const,mdR, [CmR]) soxR102(Const,mdR, [CmR]) soxR103(Const,mdR, [CmR]) soxR104(Const,mdR, [CmR]) soxR105(Const,mdR, [CmR]) soxR757(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10957 EcoliWiki soxR - Comment:
- New gene 91. Induces 9-prot.regulon when incr. intracellular O2-.,but not by other oxidants such as H2O2.see soxS dual reg. Homol.to MerR family of pos/neg regul.of MercuryR operons in Tn501&plasm.
- References:
- Tsaneva, I.R., B. Weiss 1990. soxR, a locus governing a superoxide response regulon in Escherichia coli K-12. J.Bacteriol. 172:4197-4205
- Greenberg, J.T., P.A. Monach, J.H. Chou, D. Josephy, B. Demple 1990. Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichica coli. Proc.Natl.Acad.Sci.USA 87:6181-6185
- Amabile-Cuevas, C.F., B. Demple 1991. Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon. Nucleic Acids Res. 19:4479-4484
- Wu, J., B. Weiss 1991. Two divergently transcribed genes, soxR and soxS, control a superoxide response regulon of Escherichia coli. J.Bacteriol. 173:2864-2871
- Nunoshiba, T., E. Hidalgo, C. Amabile Cuevas, B. Demple 1992. Two-stage control of an oxidative stress regulon: the Escherichia coli SoxR protein triggers redox-inducible expression of the soxS regulatory gene. J.Bacteriol. 174:6054-6060
- Nunoshiba, T., E. Hidalgo, Z.-W. Li, B. Demple 1993. Negative autoregulation by the Escherichia coli SoxS protein: a dampening mechanism for the soxRS redox stress response. J.Bacteriol. 175:7492-7494
- Nunoshiba, T., B. Demple 1994. A cluster of constitutive mutations affecting the C-terminus of the redox-sensitive SoxR transcriptional activator. Nucleic Acids Res. 22:2958-2962
- Gaudu, P., B. Weiss 1996. SoxR, a [2Fe-2S] transcription factor, is active only in its oxidized form. Proc.Natl.Acad.Sci.USA 93:10094-10098
- Hidalgo, E., B. Demple 1996. Activation of SoxR-dependent transcription in vitro by noncatalytic or NifS-mediated assembly of [2Fe-2S] clusters into apo-SoxR. J.Biol.Chem. 271:7269-7272
- Zheng, M., B. Doan, T.D. Schneider, G. Storz 1999. OxyR and SoxRS regulation of fur. J.Bacteriol. 181:4639-4643
- Demple, B., E. Hidalgo, H. Ding 1999. Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response. Biochem Soc Symp 64:119-128
- Fuentes, A.M., J.J. Diaz-Mejia, R. Maldonado-Rodriguez, C.F. Amabile-Cuevas 2001. Differential activities of the SoxR protein of Escherichia coli: SoxS is not required for gene activation under iron deprivation. FEMS Microbiol.Lett. 201:271-275