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Site hokC
- Name: hokC
- Type: Gene
- Synonyms
b4412 MG1655 locus tag gef for Gene Expression Fatal - Mnemonic: Host killing
- Left End Point: 0.36
- Right End Point: 0.37
- Products:
toxic membrane polypeptide Hok (host-killing) protein, homologous to Hok toxins of plasmid R1 - Direction: <
- Properties:
Property Comment encodes memb.of multimer.compl Gef family of toxic proteins homologous to: relF, plasmid genes hok, flmA, srnB, pndA - Priority: 0
- External Database Links:
Host Site Page Links EcoGene.org EG10373 EcoliWiki hokC - Comment:
- Other gef gene family members: relF;conjugative plasmid genes hok, flmA, srnB, and pndA. Encode small toxic proteins of ca. 50 a.a. Post-transcript.regul.via leader for gef,other mech for others.Kills
- References:
- Poulsen, L.K., N.W. Larsen, S. Molin, P. Andersson 1989. A family of genes encoding a cell-killing function may be conserved in all gram-negative bacteria. Mol.Microbiol. 3:1463-1472
- Poulsen, L.K., A. Refn, S. Molin, P. Andersson 1991. The gef gene from Escherichia coli is regulated at the level of translation. Mol.Microbiol. 5:1639-1648
- Poulsen, L.K., A. Refn, S. Molin, P. Andersson 1991. Topographic analysis of the toxic Gef protein from Escherichia coli. Mol.Microbiol. 5:1627-1637
- Poulsen, L.K., N.W. Larsen, S. Molin, P. Andersson 1992. Analysis of an Escherichia coli mutant strain resistant to the cell-killing function encoded by the gef gene family. Mol.Microbiol. 6:895-905
- Jensen, L.B., J.L. Ramos, Z. Kaneva, S. Molin 1993. A substrate-dependent biological containment system for Pseudomonas putida based on the Escherichia coli gef gene. Appl.Environ.Microbiol. 59:3713-3717
- Gerdes, K., A.P. Gultyaev, T. Franch, K. Pedersen, N.D. Mikkelsen 1997. Antisense RNA-regulated programmed cell death. Annu.Rev.Genet. 31:1-31
- Pedersen, K., K. Gerdes 1999. Multiple hok genes on the chromosome of Escherichia coli. Mol.Microbiol. 32:1090-1102