Site degP
- Name: degP
- Type: Gene
- Synonyms
b0161 MG1655 locus tag htrA - Mnemonic: degradative protease
- Left End Point: 3.90
- Right End Point: 3.93
- Products:
DegP protease, periplasmic endoprotease Protease Do a serine protease, periplasmic, endoprotease - Direction: >
- Properties:
Property Comment stress response NULL encodes a protease serine protease, endoprotease - Priority: 0
- 2 Alleles of This Gene
degP41(del)::kan degP775(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10463 EcoliWiki degP - Comment:
- transcribed from a sigma-E promoter. indispensable at high temperatures. periplasmic endoprotease. See also degQ. May function to degrade transiently degraded substrates in periplasm, e.g. HS or SOS
- References:
- Lipinska, B., S. Sharma, C. Georgopoulos 1988. Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mechanism of heat-inducible transcription. Nucleic Acids Res. 16:10053-10067
- Strauch, K.L., J.R. Beckwith 1988. An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins. Proc.Natl.Acad.Sci.USA 85:1576-1580
- Lipinska, B., O. Fayet, L. Baird, C. Georgopoulos 1989. Identification, characterization, and mapping of the Escherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures. J.Bacteriol. 171:1574-1584
- Cavard, D., C. Lazdunski, S.P. Howard 1989. The acylated precursor form of the colicin A lysis protein is a natural substrate of the DegP protease. J.Bacteriol. 171:6316-6322
- Strauch, K.L., K.R. Johnson, J.R. Beckwith 1989. Characterization of degP, a gene required for proteolysis in the cell envelope and essential for growth of Escherichia coli at high temperature. J.Bacteriol. 171:2689-2696
- Lipinska, B., M. Zylicz, C. Georgopoulos 1990. The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase. J.Bacteriol. 172:1791-1797
- Seol, J.H., S.K. Woo, E.M. Jung, S.J. Yoo, C.S. Lee, K.J. Kim, K. Tanaka, A. Ichihara, D.B. Ha, C.H. Chung 1991. Protease Do is essential for survival of Escherichia coli at high temperatures: its identity with the htrA gene product. Biochem.Biophys.Re
- Skorko-Glonek, J., A. Wawrzynow, K. Krzewski, K. Kurpierz, B. Lipinska 1995. Site-directed mutagenesis of the HtrA (DegP) serine protease, whose proteolytic activity is indispensable for Escherichia coli survival at elevated temperatures. Gene 163:47-0
- Hiratsu, K., M. Amemura, H. Nashimoto, H. Shinagawa, K. Makino 1995. The rpoE gene of Escherichia coli, which encodes sigma^E, is essential for bacterial growth at high temperature. J.Bacteriol. 177:2918-2922