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Site msbA
- Name: msbA
- Type: Gene
- Synonyms
b0914 MG1655 locus tag - Mnemonic: multicopy suppressor of htrB
- Left End Point: 20.82
- Right End Point: 20.86
- Products:
ABC transporter, flips core-lipid A from inner to outer surf. of IM. - Direction: >
- Priority: 0
- 1 Alleles of This Gene
msbA791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10613 EcoliWiki msbA - Comment:
- Lipid exporter, lipid-activated ATPase; involved with drug export and resistance.
- References:
- Karow, M, C Georgopoulos 1993. The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators. Mol. Microbiol. 7(1):69-79.
- Polissi, A., C. Georgopoulos 1996. Mutational analysis and properties of the msbA gene of Escherichia coli, coding for an essential ABC family transporter. Mol.Microbiol. 20:1221-1233
- Garrett, T.A., J.L. Kadrmas, C.H.R. Raetz 1997. Identification of the gene encoding the Escherichia coli lipid A 4'-kinase. Facile phosphorylation of endotoxin analogs with recombinant LpxK. J.Biol.Chem. 272:21855-21864
- Garrett, TA, NL Que, CR Raetz 1998. Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene. J. Biol. Chem. 273(20):12457-65.
- Doerrler, W.T., C.R. Raetz 2002. ATPase activity of the MsbA lipid flippase of Escherichia coli. J.Biol.Chem. 277:36697-36705
- Doerrler, W.T., H.S. Gibbons, C.R. Raetz 2004. MsbA-dependent translocation of lipids across the inner membrane of Escherichia coli. J.Biol.Chem. 279:45102-45109
- Woebking, B, G Reuter, RA Shilling, S Velamakanni, S Shahi, H Venter, L Balakrishnan, HW van Veen 2005. Drug-lipid A interactions on the Escherichia coli ABC transporter MsbA. J. Bacteriol. 187(18):6363-9.
- Raetz, C.R., C.M. Reynolds, M.S. Trent, R.E. Bishop 2007. Lipid A modification systems in gram-negative bacteria. Annu.Rev.Biochem. 76:295-329