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Site prc
- Name: prc
- Type: Gene
- Synonyms
b1830 MG1655 locus tag tsp tail-specific protease - Mnemonic: PBP processing, C-terminal
- Left End Point: 41.19
- Right End Point: 41.23
- Products:
tail-specific protease TSP - Direction: <
- Properties:
Property Comment encodes membrane protein periplasmic side of cytoplasmic membrane encodes a protease cleaves penicillin binding protein 3 - Priority: 0
- 1 Alleles of This Gene
prc-755(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10760 EcoliWiki prc - Comment:
- suggested to be part of the fatty acid transport system (Azizan and Black, 1994
- References:
- Nagasawa, H., Y. Sakagami, A. Suzuki, H. Suzuki, H. Hara, Y. Hirota 1989. Determination of the cleavage site involved in C-terminal processing of penicillin-binding protein 3 of Escherichia coli. J.Bacteriol. 171:5890-5893
- Hara, H., Y. Nishimura, J. Kato, H. Suzuki, H. Nagasawa, A. Suzuki, Y. Hirota 1989. Genetic analyses of processing involving C-terminal cleavage in penicillin-binding protein 3 of Escherichia coli. J.Bacteriol. 171:5882-5889
- Hara, H., Y. Yamamoto, Y. Higashitani, H. Suzuki, Y. Nishimura 1991. Cloning, mapping, and characterization of the Exhcerichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3. J.Bacteriol. 173:4799-4813
- Silber, K.R., K.C. Keiler, R.T. Sauer 1992. Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini. Proc.Natl.Acad.Sci.USA 89:295-299
- Seoane, A.S., A. Sabbaj, L.M. McMurry, S.B. Levy 1992. Multiple antibiotic susceptibility associated with inactivation of the prc-gene. J.Bacteriol. 174:7844-7847
- Azizan, A., P.N. Black 1994. Use of transposon TnphoA to identify genes for cell envelope proteins of Escherichia coli required for long-chain fatty acid transport: the periplasmic protein Tsp potentiates long-chain fatty acid transport. J.Bacteriol. 1
- Silber, K.R., R.T. Sauer 1994. Deletion of the prc (tsp) gene provides evidence for additional tail-specific proteolytic activity in Escherichia coli K-12. Mol.Gen.Genet. 242:237-240
- Keiler, K.C., K.R. Silber, K.M. Downard, I.A. Papayannopoulos, K. Biemann, R.T. Sauer 1995. C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease. Protein Sci. 4:1507-1515