Site hscA
- Name: hscA
- Type: Gene
- Synonyms
b2526 MG1655 locus tag - Mnemonic: heat shock cognate
- Left End Point: 57.23
- Right End Point: 57.27
- Products:
Hsc66, cold shock protein, chaperone - Direction: <
- Properties:
Property Comment encodes chaperone molecule probable cold shock chaperone, an Hsp70 homolog stress response induced by cold shock, but not by heat shock. - Priority: 0
- 1 Alleles of This Gene
hscA772(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG12130 EcoliWiki hscA - Comment:
- induced, eg.e. after shift from 37 to 10C. also by chloramphenicol. homolog of Hsp70. cotranscription of hscB,A, and fdx
- References:
- Seaton, B.L., L.E. Vickery 1994. A gene encoding a DnaK/hsp70 homolog in Escherichia coli. Proc.Natl.Acad.Sci.USA 91:2066-2070
- Kawula, T.H., M.J. Lelivelt 1994. Mutations in a gene encoding a new Hsp70 suppress rapid DNA inversion and bgl activation, but not proU derepression, in hns-1 mutant Escherichia coli. J.Bacteriol. 176:610-619
- Lelivelt, M.J., T.H. Kawula 1995. Hsc66, an Hsp70 homolog in Escherichia coli, is induced by cold shock but not by heat shock. J.Bacteriol. 177:4900-4907
- Vickery, L.E., J.J. Silberg, D.T. Ta 1997. Hsc66 and Hsc20, a new heat shock cognate molecular chaperone system from Escherichia coli. Protein Sci. 6:1047-1056
- Silberg, J.J., K.G. Hoff, L.E. Vickery 1998. The Hsc66-Hsc20 chaperone system in Escherichia coli: chaperone activity and interactions with the DnaK-DnaJ-grpE system. J.Bacteriol. 180:6617-6624
- Silberg, J.J., L.E. Vickery 2000. Kinetic characterization of the ATPase cycle of the molecular chaperone Hsc66 from Escherichia coli. J.Biol.Chem. 275:7779-7786