Site pcm
- Name: pcm
- Type: Gene
- Synonyms
b2743 MG1655 locus tag - Mnemonic: protein carboxyl methyltransferase
- Left End Point: 61.80
- Right End Point: 61.81
- Products:
L-isoaspartyl protein carboxyl methyltransferase PIMT, protein-L-isoaspartate(D-aspartate) O-methyltransferase - Direction: <
- Priority: 0
- 1 Alleles of This Gene
pcm-748(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10689 EcoliWiki pcm - Comment:
- doesn't repair isoaspartyl residues on (age-damaged?) proteins. pcm- mutants don't survive well in stat.phase or 55C
- References:
- Fu, J.C., L. Ding, S. Clarke 1991. Purification, gene cloning, and sequence analysis of an L-isoaspartyl protein carboxyl methyltransferase from Escherichia coli. J.Biol.Chem. 266:14562-14572
- Li, C., S. Clarke 1992. A protein methyltransferase specific for altered aspartyl residues is important in Escherichia coli stationary-phase survival and heat-shock resistance. Proc.Natl.Acad.Sci.USA 89:9885-9889
- Li, C., P.Y. Wu, M. Hsieh 1997. Growth-phase-dependent transcriptional regulation of the pcm and surE genes required for stationary-phase survival of Escherichia coli. Microbiology 143:3513-3520
- Visick, J., H. Cai, S. Clarke 1998. The L-isoaspartyl protein repair methyltransferase enhances survival of aging Escherichia coli subjected to secondary environmental stresses. J.Bacteriol. 180:2623-2629
- David, C.L., J. Keener, D.W. Aswad 1999. Isoaspartate in ribosomal protein S11 of Escherichia coli. J.Bacteriol. 181:2872-2877