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Site parC
- Name: parC
- Type: Gene
- Synonyms
b3019 MG1655 locus tag - Mnemonic: partition
- Left End Point: 68.15
- Right End Point: 68.20
- Products:
topoisomerase IV subunit - Direction: <
- Properties:
Property Comment affects cell division/growth NULL quinolone (nal,ciprofloxacin)R in presence of gyrA(nalR) mutation, becomes resistant to killing by ciprofloxacin, more potent quinolone than nal - Priority: 0
- 3 Alleles of This Gene
parC789(del)::kan parC791-YFP(::cat) parC792-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10686 EcoliWiki parC - Comment:
- unlinks daughter replicons. see phenotype parC gyrA quinolone-resistance (ciprofloxacin)
- References:
- Kato, J., Y. Nishimura, M. Yamada, H. Suzuki, Y. Hirota 1988. Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli. J.Bacteriol. 170:3967-3977
- Kato, J., Y. Nishimura, R. Imamura, H. Niki, S. Hiraga, H. Suzuki 1990. New topoisomerase essential for chromosome segregation in E. coli. Cell 63:393-404
- Kato, J., H. Suzuki, H. Ikeda 1992. Purification and characterization of DNA topoisomerase IV in Escherichia coli. J.Biol.Chem. 267:25676-25684
- Peng, H., K.J. Marians 1993. Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions. J.Biol.Chem. 268:24481-24490
- Zechiedrich, E.L., N.R. Cozzarelli 1995. Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 9:2859-2869
- Khodursky, A.B., E.L. Zechiedrich, N.R. Cozzarelli 1995. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc.Natl.Acad.Sci.USA 92:11801-11805
- Peng, H., K.J. Marians 1995. The interaction of Escherichia coli topoisomerase IV with DNA. J.Biol.Chem. 270:25286-25290
- Heisig, P. 1996. Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli. Antimicrob.Agents Chemother. 40:879-885
- Chen, C.R., M. Malik, M. Snyder, K. Drlica 1996. DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage. J.Mol.Biol. 258:627-637
- Kumagai, Y., J.I. Kato, K. Hoshino, T. Akasaka, K. Sato, H. Ikeda 1996. Quinolone-resistant mutants of Escherichia coli DNA topoisomerase IV parC gene. Antimicrob.Agents Chemother. 40:710-714
- Bagel, S, V Hullen, B Wiedemann, P Heisig 1999. Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli. Antimicrob. Agents Chemother. 43(4):868-75.
- Zechiedrich, E.L., A.B. Khodursky, S. Bachellier, R. Schneider, D. Chen, D.M. Lilley, N.R. Cozzarelli 2000. Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J.Biol.Chem. 275:8103-8113