Site greA
- Name: greA
- Type: Gene
- Synonyms
b3181 MG1655 locus tag - Mnemonic: growth regulation
- Left End Point: 71.69
- Right End Point: 71.70
- Products:
transcription elongation factor transcript cleavage factor - Direction: <
- Priority: 0
- 1 Alleles of This Gene
greA788(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10415 EcoliWiki greA - Comment:
- transcription elongation factor. increases fidelity of transcription. Under non-heat-shock conditions co-transcribed with ftsJ and hflB, under heat-shock conditions not transcribed with ftsJ-hflB op.
- References:
- Sparkowski, J., A. Das 1990. The nucleotide sequence of greA, a suppressor gene that restores growth of an Escherichia coli RNA polymerase mutant at high temperature. Nucleic Acids Res. 18:6443-0
- Sparkowski, J., A. Das 1991. Location of a new gene, greA, on the Escherichia coli chromosome. J.Bacteriol. 173:5256-5257
- Borukhov, S., A. Polyakov, V. Nikiforov, A. Goldfarb 1992. GreA-protein: a transcription elongation factor from Escherichia coli. Proc.Natl.Acad.Sci.USA 89:8899-8902
- Erie, D.A., O. Hajiseyedjavadi, M.C. Young, P.H. von Hippel 1993. Multiple RNA polymerase conformations and GreA: control of the fidelity of transcription. Science 262:867-873
- Borukhov, S., V. Sagitov, A. Goldfarb 1993. Transcript cleavage factors from E. coli. Cell 72:459-466
- Nudler, E., A. Goldfarb, M. Kashlev 1994. Discontinuous mechanism of transcription elongation. Science 265:793-796
- Altmann, C.R., D.E. Solow-Cordero, M.J. Chamberlin 1994. RNA cleavage and chain elongation by Escherichia coli DNA-dependent RNA polymerase in a binary enzyme.RNA complex. Proc.Natl.Acad.Sci.USA 91:3784-3788
- Hsu, L.M., N.V. Vo, M.J. Chamberlin 1995. Escherichia coli transcript cleavage factors GreA and GreB stimulate promoter escape and gene expression in vivo and in vitro. Proc.Natl.Acad.Sci.USA 92:11588-11592
- Stebbins, C.E., S. Borukhov, M. Orlova, A. Polyakov, A. Goldfarb, S.A. Darst 1995. Crystal structure of the GreA transcript cleavage factor from Escherichia coli. Nature 373:636-640