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Site purU
- Name: purU
- Type: Gene
- Synonyms
b1232 MG1655 locus tag tgs transient glycine starvation - Mnemonic: Purine
- Left End Point: 27.74
- Right End Point: 27.76
- Products:
formyltetrahydrofolate hydrolase - Direction: <
- Properties:
Property Comment regulatory gene balances pools of FH4 and C1-FH4 - Priority: 0
- 1 Alleles of This Gene
purU741(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG11819 EcoliWiki purU - Comment:
- C-terminal segment has homology with purN. Provides formate for purT-dependent synthesis of FGAR in third step of denovo pur biosynthesis.
- References:
- Nagy, P.L., G.M. McCorkle, H. Zalkin 1993. purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis. J.Bacteriol. 175:7066-7073
- Bosl, M. 1993. Genetic map of the tyrT region of Escherichia coli from 27.1 to 27.7 minutes based exclusively on sequence data. J.Bacteriol. 175:7751-7753
- Bosl, M., H. Kersten 1994. Organization and functions of genes in the upstream region of tyrT of Escherichia coli: phenotypes of mutants with partial deletion of a new gene (tgs). J.Bacteriol. 176:221-231
- Nagy, P.L., A. Marolewski, S.J. Benkovic, H. Zalkin 1995. Formyltetrahydrofolate hydrolase, a regulatory enzyme that functions to balance pools of tetrahydrofolate and one-carbon tetrahydrofolate adducts in Escherichia coli. J.Bacteriol. 177:1292-1298