Site nrdA
- Name: nrdA
- Type: Gene
- Synonyms
b2234 MG1655 locus tag dnaF - Mnemonic: nucleotide reductase
- Left End Point: 50.50
- Right End Point: 50.55
- Products:
ribonucleoside diphosphate reductase subunit B1 - Direction: >
- Priority: 1
- 2 Alleles of This Gene
nrdA1(ts) nrdA791-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank K02672 EcoGene.org EG10660 EcoliWiki nrdA - Comment:
- Selectable phenotype. Increase: hydroxyurea resistance?
- References:
- Fuchs, J.A., H.O. Karlstrom 1976. Mapping of nrdA and nrdB in Escherichia coli K-12. J.Bacteriol. 128:810-814
- Filpula, D. 1978. Regulation of ribonucleoside diphosphate reductase synthesis in Escherichia coli: specific activity of the enzyme in relationship to perturbations of DNA replication. J.Bacteriol. 135:429-435
- Platz, A., B.-M. Sjoberg 1980. Construction and characterization of hybrid plasmids containing the Escherichia coli region. J.Bacteriol. 143:561-568
- Yamada, M., Y. Takeda, K. Okamoto, Y. Hirota 1982. Physical map of the nrdA-nrdB-ftsB-glpT region of the chromosomal DNA of Escherichia coli. Gene 18:309-318
- Hanke, P.D., J.A. Fuchs 1983. Regulation of ribonucleoside diphosphate reductase mRNA synthesis in Escherichia coli. J.Bacteriol. 154:1040-1045
- Carlson, J., J.A. Fuchs, J. Messing 1984. Primary structure of the Escherichia coli ribonucleoside diphosphate reductase operon. Proc.Natl.Acad.Sci.USA 81:4294-4297
- Sjoberg, B.M., S. Eriksson, H. Jornvall, M. Carlquist, H. Eklund 1985. Protein B1 of ribonucleotide reductase.Direct analytical data and comparisons with data indirectly deduced from the nucleotide sequence of the Escherichia coli nrdA gene. Eur.J.Bioc
- Tuggle, C.K., J.A. Fuchs 1986. Regulation of the operon encoding ribonucleotide reductase in Escherichia coli: evidence for both positive and negative control. EMBO J. 5:1077-1085
- Nilsson, O., A. Aberg, T. Lundqvist, B.-M. Sjoberg 1988. Nucleotide sequence of the gene coding for the large subunit of ribonucleotide reductase of Escherichia coli. Nucleic Acids Res. 16:4174-0
- Tuggle, C.K., J.A. Fuchs 1990. Regulation of the operon encoding ribonucleotide reductase: role of the negative sites in nrd repression. J.Bacteriol. 172:1711-1718
- Sun, L., J.A. Fuchs 1992. Escherichia coli ribonucleotide reductase expression is cell cycle regulated. Mol.Biol.Cell 3:1095-1105
- Sun, L., B.A. Jacobson, B.S. Dien, F. Srienc, J.A. Fuchs 1994. Cell cycle regulation of the Escherichia coli nrd operon: requirement for a cis-acting upstream AT-rich sequence. J.Bacteriol. 176:2415-2426
- Sun, L., J.A. Fuchs 1994. Regulation of the Escherichia coli nrd operon: role of DNA supercoiling. J.Bacteriol. 176:4617-4626
- Kasrayan, A., A.L. Persson, M. Sahlin, B.M. Sjoberg 2002. The conserved active site asparagine in class I ribonucleotide reductase is essential for catalysis. J.Biol.Chem. 277:5749-5755