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Site nadB
- Name: nadB
- Type: Gene
- Synonyms
b2574 MG1655 locus tag nic - Mnemonic: Nicotinamide adenine dinucleotide
- Left End Point: 58.38
- Right End Point: 58.42
- Products:
quinolinate synthetase, B protein L-aspartate oxidase - Direction: >
- Priority: 1
- 7 Alleles of This Gene
nadB0 nadB3140::Tn10kan nadB4 nadB51::Tn10 nadB7 nadB742(del)::kan nadB9999 - External Database Links:
Host Site Page Links EcoGene.org EG10631 EcoliWiki nadB - Comment:
- first step in biosynthesis of pyridine nucleotides. nicotinic acid growth requirement
- References:
- Flachmann, R., N. Kunz, J. Seifert, M. Gutlich, F.J. Wientjes, A. Laufer, H.G. Gassen 1988. Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli. Cloning and characterization of quinolinate synthesis genes nadA and nadB. Eur. J. Biochem. 175:221-228.
- Seifert, J., N. Kunz, R. Flachmann, A. Laufer, K.D. Jany, H.G. Gassen 1990. Expression of the E. coli nadB gene and characterization of the gene product L-aspartate oxidase. Biol.Chem.Hoppe-Seyler 371:239-28
- Mortarino, M., A. Negri, G. Tedeschi, T. Simonic, S. Duga, H.G. Gassen, S. Ronchi 1996. L-aspartate oxidase from Escherichia coli.I.Characterization of coenzyme binding and product inhibition. Eur.J.Biochem. 239:418-426
- Tedeschi, G., A. Negri, M. Mortarino, F. Ceciliani, T. Simonic, L. Faotto, S. Ronchi 1996. L-aspartate oxidase from Escherichia coli. II. Interaction with C4 dicarboxylic acids and identification of a novel L-aspartate: fumarate oxidoreductase activity