Site mutL
- Name: mutL
- Type: Gene
- Synonyms
b4170 MG1655 locus tag - Mnemonic: Mutator
- Left End Point: 94.74
- Right End Point: 94.78
- Products:
methyl-directed mismatch repair pathway protein - Direction: >
- Properties:
Property Comment repair system gene mediates methyl-directed mismatch repair - Priority: 1
- 4 Alleles of This Gene
mutL13 mutL218::Tn10 mutL720(del)::kan mutL792-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank L19346 EcoGene.org EG11281 EcoliWiki mutL - Comment:
- Mismatch repair. Selectable phenotype. Streptomycin resistance; azaserine resistance; chemostat growth.
- References:
- Siegel, E., V. Bryson 1967. Mutator gene of Escherichia coli. J.Bacteriol. 94:38-47
- Helling, R.B. 1968. Selection of a mutant of Escherichia coli which has high mutation rates. J.Bacteriol. 96:975-980
- Cox, E.C., T. Gibson 1974. Selection for high mutation rates in chemostats. Genetics 77:169-184
- Tsui, H.C., G. Zhao, G. Feng, H.C. Leung, M.E. Winkler 1994. The mutL repair gene of Escherichia coli K-12 forms a superoperon with a gene encoding a new cell-wall amidase. Mol.Microbiol. 11:189-202
- Tsui, H.C., H.C. Leung, M.E. Winkler 1994. Characterization of broadly pleiotropic phenotypes caused by an hfq insertion mutation in Escherichia coli K-12. Mol.Microbiol. 13:35-49
- Feng, G., M.E. Winkler 1995. Single-step purifications of His6-MutH, His6-MutL and His6-MutS repair proteins of Escherichia coli K-12. Biotechniques 19:956-965
- Tsui, H.-C.T., G. Feng, M.E. Winkler 1996. Transcription of the mutL repair, miaA tRNA modification, hfq pleiotropic regulator, and hflA region protease genes of Escherichia coli K-12 from clustered Esigma^32-specific promoters during heat shock. J.Bac
- Aronshtam, A., M.G. Marinus 1996. Dominant negative mutator mutations in the mutL gene of Escherichia coli. Nucleic Acids Res. 24:2498-2504
- Drotschmann, K., A. Aronshtam, H.J. Fritz, M.G. Marinus 1998. The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA. Nucleic Acids Res. 26:948-953
- Hall, M.C., J.R. Jordan, S.W. Matson 1998. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. EMBO J. 17:1535-1541