Site metH
- Name: metH
- Type: Gene
- Synonyms
b4019 MG1655 locus tag - Mnemonic: Methionine
- Left End Point: 90.99
- Right End Point: 91.07
- Products:
B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase methionine synthase, cobalamin-dependent - Direction: >
- Priority: 1
- 2 Alleles of This Gene
metH156 metH786(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank J04975 EcoGene.org EG10587 EcoliWiki metH - Comment:
- transfers Me group from Me-cobalamin enzyme to homocysteine, generating methionine and the Cob enzyme, then THF and Me-Cob.
- References:
- Old, I.G., M.G. Hunter, D.T.R. Wilson, S.M. Knight, C.A. Weatherston, R.E. Glass 1988. Cloning and characterization of the genes for the two homocysteine transmethylases of Escherichia coli. Mol.Gen.Genet. 211:78-87
- Banerjee, R.V., N.L. Johnston, J.K. Sobeski, P. Datta, R.G. Matthews 1989. Cloning and sequence analysis of the Escherichia coli metH gene encoding cobalamin-dependent methionine synthase and isolation of a tryptic fragment containing the cobalamin-bin
- Old, I.G., D. Margarita, R.E. Glass, I. Saint Girons 1990. Nucleotide sequence of the metH gene of Escherichia coli K-12 and comparison with that of Salmonella typhimurium. Gene 87:15-21
- Marconi, R., J. Wigboldus, H. Weissbach, N. Brot 1991. Transcriptional start and MetR binding sites on the Escherichia coli metH gene. Biochem.Biophys.Res.Commun. 175:1057-1063