Site dcd
- Name: dcd
- Type: Gene
- Synonyms
b2065 MG1655 locus tag paxA - Mnemonic: dCTP deaminase
- Left End Point: 46.12
- Right End Point: 46.15
- Products:
dCTP deaminase 2-alpha-deoxycytidine 5-alpha-triphosphate deaminase - Direction: <
- Priority: 1
- 3 Alleles of This Gene
dcd-1 dcd-763(del)::kan dcd-791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG11418 EcoliWiki dcd - Comment:
- Selectable Phenotype. Deleted in phage P2 eductants; now 5-bromodeoxyuridine sensitive. dcd mutants suppress lethal dut mutations, probably by reducing accum. of dUTP (Wang and Weiss)
- References:
- Neuhard, J., K. Thomassen 1976. Altered deoxyribonucleotide pools in P2 eductants of Escherichia coli K-12 due to deletion of the dcd gene. J.Bacteriol. 126:999-1001
- Wang, L., B. Weiss 1992. dcd (dCTP deaminase) gene of Escherichia coli: mapping, cloning, sequencing, and identification as a locus of suppressors of lethal dut (dUTPase) mutations. J.Bacteriol. 174:5647-5653
- Estevenon, A.M., J. Kooistra, N. Sicard 1995. An Escherichia coli strain deficient for both exonuclease V and deoxycytidine triphosphate deaminase shows enhanced sensitivity to ionizing radiation. Mol.Gen.Genet. 246:514-518