Site crr
- Name: crr
- Type: Gene
- Synonyms
b2417 MG1655 locus tag gsr iex tgs - Mnemonic: Carbohydrate repression resistance
- Left End Point: 54.62
- Right End Point: 54.63
- Products:
IIAglc (or IIIglc) of the PTS phosphocarrier protein for glucose of the PTS; IIIglc, IIAglc - Direction: >
- Priority: 1
- 2 Alleles of This Gene
crr-10(del)::kan crr-746(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10165 EcoliWiki crr - Comment:
- Selectable Phenotype. crr/iex confusion; Loss: 5-thioglucose resistance; deleted with cysK; deleted with ptsH, I; Loss, in ptsH-, I-: growth on glycerol + a-methylgucloside. Inhibits LacY transport
- References:
- Kornberg, H.L., P.D. Watts 1978. Roles of crr-gene products in regulating carbohydrate uptake by Escherichia coli. FEBS Lett. 89:329-332
- Burd, G.I., T.R. Gabrielyan, T.N. Bol'shakova, V.N. Gershanovich 1980. Study of linkage with pts genes of pleiotropic mutation affecting expression of catabolite-sensitive genes in Escherichia coli K-12. Soviet Genet. 16:622-629
- Meadow, N.D., D.W. Saffen, R.P. Dottin, S. Roseman 1982. Molecular cloning of the crr gene and evidence that it is the structural gene for IIIGlc, a phosphocarrier protein of the bacterial phosphotransferase system. Proc.Natl.Acad.Sci.USA 79:2528-2532
- Britton, P., D. Murfitt, F. Parra, M.C. Jones-Mortimer, H.L. Kornberg 1982. Phosphotransferase-mediated regulation of carbohydrate utilization in Escherichia coli K12: identification of the products of genes on the specialized transducing phages LAM ie
- Britton, P., A. Boronat, D.A. Hartley, M.C. Jones-Mortimer, H.L. Kornberg, F. Parra 1983. Phosphotransferase-mediated regulation of carbohydrate utilization in Escherichia coli K12: location of the gsr (tgs) and iex (crr) genes by specialized transduc
- Nelson, S.O., J.W. Lengeler, P.W. Postman 1984. Role of III$^{Glc}$ of the phosphoenol pyruvate-glucose phosphotransferase system in inducer exclusion in Escherichia coli. J.Bacteriol. 160:360-364
- De Reuse, H., E. Huttner, A. Danchin 1984. Analysis of the ptsH-ptsI-crr region in Escherichia coli K-12: evidence for the existence of a single transcriptional unit. Gene 32:31-40
- Saffen, D.W., K.A. Presper, T.L. Doering, S. Roseman 1987. Sugar transport by the bacterial phosphotransferase system. Molecular cloning and structural analysis of the Escherichia coli ptsH, ptsI and crr genes. J.Biol.Chem. 262:16241-16253
- De Reuse, H., A. Danchin 1988. The ptsH, ptsI, and crr genes of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system: a complex operon with several modes of transcription. J.Bacteriol. 170:3827-3837
- Brun, Y.V., R. Breton, P. Lanouette, J. LaPointe 1990. Precise mapping and comparison of two evolutionarily related regions of the Escherichia coli K-12 chromosome. Evolution of valU and lysT from an ancestral tRNA operon. J.Mol.Biol. 214:825-843
- Buhr, A., G.A. Daniels, B. Erni 1992. The glucose transporter of Escherichia coli. Mutants with impaired translocation activity that retain phosphorylation activity. J.Biol.Chem. 267:3847-3851
- Parra-Lopez, C., M.T. Baer, E.A. Groisman 1993. Molecular genetic analysis of a locus required for resistance to antimicrobial peptides in Salmonella typhimurium. EMBO J. 12:4053-4062
- Holtman, C.K., A.C. Pawlyk, N. Meadow, S. Roseman, D.W. Pettigrew 2001. IIA(Glc) allosteric control of Escherichia coli glycerol kinase: binding site cooperative transitions and cation-promoted association by Zinc(II). Biochemistry 40:14302-14308