Site exbB
- Name: exbB
- Type: Gene
- Synonyms
b3006 MG1655 locus tag - Mnemonic: export
- Left End Point: 67.88
- Right End Point: 67.90
- Products:
membrane protein required for TonB-dependent energy transduction and TonB stability TonB-ExbB-ExbD cytoplasmic membrane-anchored complex component - Direction: <
- Properties:
Property Comment encodes membrane protein TonB-ExbB-ExbD complex transfers energy to open channels in OMP receptors; couples action of OM transporters FhuA and BtuB across cytopl.memb. - Priority: 1
- 2 Alleles of This Gene
exbB41 exbB779(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10271 EcoliWiki exbB - Comment:
- Uptake of enterochelin; resistance or sensitivity to colicins. Selectable phenotype. Colicin B, colicin I, other colicin resistance. Strong homology to TolQ (and exbD homol. tolR)
- References:
- Guterman, S.K., L. Dann 1973. Excretion of enterochelin by exbA and exbB mutants of Escherichia coli. J.Bacteriol. 114:1225-1230
- Pugsley, A.P., P.R. Reeves 1976. Iron uptake in colicin B-resistant mutants of Escherichia coli K-12. J.Bacteriol. 126:1052-1062
- Eick-Helmerich, K., K. Hantke, V. Braun 1987. Cloning and expression of the exbB gene of Escherichia coli K-12. Mol.Gen.Genet. 206:246-251
- Fischer, E., K. Gunter, V. Braun 1989. Involvement of ExbB and TonB in transport across the outer membrane of Escherichia coli: phenotypic complementation of exb mutants by overexpressed tonB and physical stabilization of TonB by ExbB. J.Bacteriol. 171
- Eick-Helmerich, K., V. Braun 1989. Import of biopolymers into Escherichia coli: nucleotide sequences of the exbB and exbD genes are homologous to those of the tolQ and tolR genes, respectively. J.Bacteriol. 171:5117-5126
- Braun, V. 1989. The structurally related exbB and tolQ genes are interchangeable in conferring tonB-dependent colicin, bacteriophage, and albomycin sensitivity. J.Bacteriol. 171:6387-6390
- Braun, V., C. Herrmann 1993. Evolutionary relationship of uptake systems for biopolymers in Escherichia coli: cross-complementation between the TonB-ExbB-ExbD and the TolA-TolQ-TolR proteins. Mol.Microbiol. 8:261-268
- Karlsson, M., K. Hannavy, C.F. Higgins 1993. ExbB acts as a chaperone-like protein to stabilize TonB in the cytoplasm. Mol.Microbiol. 8:389-396
- Kampfenkel, K., V. Braun 1993. Topology of the ExbB protein in the cytoplasmic membrane of Escherichia coli. J.Biol.Chem. 268:6050-6057
- Killmann, H., V. Braun 1994. Energy-dependent receptor activities of Escherichia coli K-12: mutated TonB proteins alter FhuA receptor activities to phages T5, T1, phi80 and to colicin M. FEMS Microbiol.Lett. 119:71-76
- Ahmer, B.M., M.G. Thomas, R. Larsen, K. Postle 1995. Characterization of the exbBD operon of Escherichia coli and the role of ExbB and ExbD in TonB function and stability. J.Bacteriol. 177:4742-4747