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Site secA
- Name: secA
- Type: Gene
- Synonyms
azi b0098 MG1655 locus tag pea prlD - Mnemonic: secretory (monitor)
- Left End Point: 2.33
- Right End Point: 2.39
- Products:
translocation ATPase for protein export preprotein translocase ATP-driven motor protein in protein translocation, RNA helicase activity - Direction: >
- Properties:
Property Comment encodes memb.of multimer.compl for protein export encodes membrane protein but also found free in cytosol essential gene NULL - Priority: 1
- 13 Alleles of This Gene
secA201(aziR) secA202(aziR) secA203(aziR) secA204(aziR) secA205(aziR) secA206(aziR) secA207(aziR) secA209(aziR) secA214(aziR) secA215 secA216 secA51(ts) secA791-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank M20791 EcoGene.org EG10936 EcoliWiki secA - Comment:
- References:
- Oliver, D.B., J.R. Beckwith 1981. E. coli mutant pleiotropically defective in the export of secreted proteins. Cell 25:765-772
- Oliver, D.B., J.R. Beckwith 1982. Identification of a new gene (secA) and gene product involved in the secretion of envelope proteins in Escherichia coli. J.Bacteriol. 150:686-691
- Cabelli, R.J., L. Chen, P.C. Tai, D.B. Oliver 1988. SecA protein is required for secretory protein translocation into E. coli membrane vesicles. Cell 55:683-692
- Schmidt, M.G., E.E. Rollo, J. Grodberg, D.B. Oliver 1988. Nucleotide sequence of the secA gene and secA(Ts) mutations preventing protein export in Escherichia coli. J.Bacteriol. 170:3404-3414
- Fikes, J.D., P.J. Bassford 1989. Novel secA alleles improve export of maltose-binding protein synthesized with a defective signal peptide. J.Bacteriol. 171:402-409
- Oliver, D.B., R.J. Cabelli, G.P. Jarosik 1990. SecA protein: autoregulated initiator of secretory precursor protein translocation across the E. coli plasma membrane. J.Bioenerg.Biomembr. 22:311-336
- Bieker, K.L., G.J. Phillips, T.J. Silhavy 1990. The sec and prl genes of Escherichia coli. J.Bioenerg.Biomembr. 22:291-310
- Oliver, D.B., R.J. Cabelli, K.M. Dolan, G.P. Jarosik 1990. Azide-resistant mutants of Escherichia coli alter the SecA protein, an azide-sensitive component of the protein export machinery. Proc.Natl.Acad.Sci.USA 87:8227-8231
- Fortin, Y., P. Phoenix, G.R. Drapeau 1990. Mutations conferring resistance to azide in Escherichia coli occur primarily in the secA gene. J.Bacteriol. 172:6607-6610
- Jarosik, G.P., D.B. Oliver 1991. Isolation and analysis of dominant secA mutations in Escherichia coli. J.Bacteriol. 173:860-868
- Kosic, N., M. Sugai, C.K. Fan, H.C. Wu 1993. Processing of lipid-modified prolipoprotein requires energy and sec gene products in vivo. J.Bacteriol. 175:6113-6117
- Chun, S.-Y., L.L. Randall 1994. In vivo studies of the role of SecA during protein export in Escherichia coli. J.Bacteriol. 176:4197-4203
- Douville, K., A. Price, J. Eichler, A. Economou, W. Wickner 1995. SecYEG and SecA are the stoichiometric components of preprotein translocase. J.Biol.Chem. 270:20106-20111
- Danese, P.N., C.K. Murphy, T.J. Silhavy 1995. Multicopy suppression of cold-sensitive sec mutations in Escherichia coli. J.Bacteriol. 177:4969-4973
- Salavati, R., D. Oliver 1995. Competition between ribosome and SecA binding promotes Escherichia coli secA translational regulation. RNA 1:745-753
- Park, S.K., D.W. Kim, J. Choe, H. Kim 1997. RNA helicase activity of Escherichia coli SecA protein. Biochem.Biophys.Res.Commun. 235:593-597
- Sarker, S., D. Oliver 2002. Critical regions of secM that control its translation and secretion and promote secretion-specific secA regulation. J.Bacteriol. 184:2360-2369