Site hepA
- Name: hepA
- Type: Gene
- Synonyms
b0059 MG1655 locus tag rapA - Mnemonic: helicase-like protein
- Left End Point: 1.30
- Right End Point: 1.36
- Direction: <
- Properties:
Property Comment putative:seq./homol.based NULL - Priority: 0
- 2 Alleles of This Gene
hepA769(del)::kan hepA791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG11083 EcoliWiki hepA - Comment:
- Downstream, counterclockwise from polB.An orf w/homol.to SNF2 family of proteins w/helicase motifs but no demon.helicase activity; not LexA-regul.Motifs simil. to ones in RecQ, UvrB; also yeast Rad3.
- References:
- Lewis, L.K., M.E. Jenkins, D.W. Mount 1992. Isolation of DNA damage-inducible promoters in Escherichia coli: regulation of polB (dinA), dinG, and dinH by LexA repressor. J.Bacteriol. 174:3377-3385
- Bork, P., E.V. Koonin 1993. An expanding family of helicases within the `DEAD/H' superfamily. Nucleic Acids Res. 21:751-752
- Eisen, J.A., K.S. Sweder, P.C. Hanawalt 1995. Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. Nucleic Acids Res. 23:2715-2723
- Muzzin, O., E.A. Campbell, L. Xia, E. Severinova, S.A. Darst, K. Severinov 1998. Disruption of Escherichia coli hepA, an RNA polymerase-associated protein, causes UV sensitivity. J.Biol.Chem. 273:15157-15161
- Sukhodolets, M.V., D.J. Jin 1998. RapA, a novel RNA polymerase-associated protein, is a bacterial homolog of SWI2/SNF2. J.Biol.Chem. 273:7018-7023