Site degS
- Name: degS
- Type: Gene
- Synonyms
b3235 MG1655 locus tag hhoB Bass, ref. below, for htrA homolog htrH - Mnemonic: degradative protease
- Left End Point: 72.85
- Right End Point: 72.88
- Products:
a serine protease, periplasmic, endoprotease - Direction: >
- Properties:
Property Comment encodes membrane protein membrane anchored protease - Priority: 0
- External Database Links:
Host Site Page Links EcoGene.org EG11652 EcoliWiki degS - Comment:
- Sequential proteolytic cleavage by DegS and YaeL of RseA, which transduces stress signal across inner membrane, activates the sigmaE pathway responding to protein misfolding in envelope
- References:
- Bass, S. 1994. GenBank and Pers.Comm. U1566:0-0
- Bass, S., Q. Gu, A. Christen 1996. Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated RlpA. J.Bacteriol. 178:1154-1161
- Waller, P.R.H., R.T. Sauer 1996. Characterization of degQ and degS, Escherichia coli genes encoding homologs of the DegP protease. J.Bacteriol. 178:1146-1153
- Alba, B.M., J.A. Leeds, C. Onufryk, C.Z. Lu, C.A. Gross 2002. DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response. Genes Dev. 16:2156-2168