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Site polB
- Name: polB
- Type: Gene
- Synonyms
b0060 MG1655 locus tag dinA damage-inducible - Mnemonic: polymerase
- Left End Point: 1.37
- Right End Point: 1.42
- Products:
DNA polymerase II - Direction: <
- Properties:
Property Comment SOS-related NULL lexA regulon NULL - Priority: 1
- 2 Alleles of This Gene
polB100 polB770(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank X54847 NCBI/GenBank M35371 EcoGene.org EG10747 EcoliWiki polB - Comment:
- Identical with dinA, regul. by LexA repressor, not required for growth, UV-repair or UV-mutagenesis. Enz. can be isol. from SOS-induced cells.
- References:
- Chen, H., S.K. Bryan, R.E. Moses 1989. Cloning the polB gene of Escherichia coli and identification of its product. J.Biol.Chem. 264:20591-20595
- Chen, H., Y. Sun, T.F. Stark, W.G. Beattie, R.E. Moses 1990. Nucleotide sequence and deletion analysis of the polB gene of Escherichia coli. DNA Cell Biology 9:631-635
- Bonner, C.A., S. Hays, K. McEntee, M.F. Goodman 1990. DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli. Proc.Natl.Acad.Sci.USA 87:7663-7667
- Iwasaki, H., Y. Ishino, H. Toh, A. Nakata, H. Shinagawa 1991. Escherichia coli DNA polymerase II is homologous to alpha-like DNA polymerases. Mol.Gen.Genet. 226:24-33
- Shinagawa, H., H. Iwasaki, Y. Ishino, A. Nakata 1991. SOS-inducible DNA polymerase II of E. coli is homologous to replicative DNA polymerase of eukaryotes. Biochimie 73:433-435
- Lewis, L.K., M.E. Jenkins, D.W. Mount 1992. Isolation of DNA damage-inducible promoters in Escherichia coli: regulation of polB (dinA), dinG, and dinH by LexA repressor. J.Bacteriol. 174:3377-3385
- Escarceller, M., J. Hicks, G. Gudmundsson, G. Trump, D. Touati, S.T. Lovett, P.L. Foster, K. McEntee, M.F. Goodman 1994. Involvement of Escherichia coli DNA polymerase II in response to oxidative damage and adaptive mutation. J.Bacteriol. 176:6221-6228
- Paz-Elizur, T., M. Takeshita, M. Goodman, M. O'Donnell, Z. Livneh 1996. Mechanism of translesion DNA synthesis by DNA polymerase II. Comparison to DNA polymerases I and III core. J.Biol.Chem. 271:24662-24669
- Tomer, G., O. Cohen-Fix, M.A. O'Donnell, M. Goodman, Z. Livneh 1996. Reconstitution of repair-gap UV mutagenesis with purified proteins from Escherichia coli: a role for DNA polymerases III and II. Proc.Natl.Acad.Sci.USA 93:1376-1380
- Berardini, M., P.L. Foster, E.L. Loechler 1999. DNA polymerase II (polB) is involved in a new DNA repair pathway for DNA interstrand cross-links in Escherichia coli. J.Bacteriol. 181:2878-2882