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Site lexA
- Name: lexA
- Type: Gene
- Synonyms
b4043 MG1655 locus tag exrA spr tsl temperature sensitive lex umuA - Mnemonic: lambda excision
- Left End Point: 91.71
- Right End Point: 91.72
- Products:
LexA repressor of SOS regulon - Direction: >
- Properties:
Property Comment regulatory gene global regulator - Priority: 1
- 14 Alleles of This Gene
lexA1(Ind-) lexA101 lexA102 lexA103 lexA104 lexA105 lexA106 lexA107 lexA108 lexA109 lexA3(Ind-) lexA41(ts) lexA51 lexA71::Tn5 - External Database Links:
Host Site Page Links NCBI/GenBank J01643 EcoGene.org EG10533 EcoliWiki lexA - Comment:
- Represses ca. 20 SOS genes; under SOS conditions RecA is activated to a form that increases rate of LexA cleavage and inactivation. LexA is self-processing, but cleavage is very low in absence of RecA
- References:
- Brent, R., M. Ptashne 1980. The lexA gene product represses its own promoter. Proc.Natl.Acad.Sci.USA 77:1932-1936
- Little, R. 1980. Isolation of recombinant plasmids and phage carrying the lexA gene of Eschericia coli K-12. Gene 10:237-247
- Brent, R., M. Ptashne 1981. Mechanism of action of the lexA gene product. Proc.Natl.Acad.Sci.USA 78:4204-4208
- Markham, B.E., J.W. Little, D.W. Mount 1981. Nucleotide sequence of the lexA gene of Escherichia coli K-12. Nucleic Acids Res. 9:4149-4161
- Little, J.W., D.W. Mount, C.R. Yanisch-Perron 1981. Purified lexA protein is a repressor of the recA and lexA genes. Proc.Natl.Acad.Sci.USA 78:4199-4203
- Horii, T., T. Ogawa, H. Ogawa 1981. Nucleotide sequence of the lexA gene of E. coli. Cell 23:689-697
- Miki, T., Y. Ebina, F. Kishi, A. Nakazawa 1981. Organization of the lexA gene of Escherichia coli and nucleotide sequence of the regulatory region. Nucleic Acids Res. 9:529-543
- Brandsma, J.A., J. Stoorvogel, C.A. Van Sluis, P. Van de Putte 1982. Effect of lexA and ssb genes, present on a uvrA recombinant plasmid, on the UV survival of Escherichia coli K-12. Gene 18:77-85
- Harmon, F.G., W.M. Rehrauer, S.C. Kowalczykowski 1996. Interaction of Escherichia coli RecA protein with LexA repressor. II. Inhibition of DNA strand exchange by the uncleavable LexA S119A repressor argues that recombination and SOS induction are compe
- Shepley, D.P., J.W. Little 1996. Mutant LexA proteins with specific defects in autodigestion. Proc.Natl.Acad.Sci.USA 93:11528-11533
- Hill, T.M., B. Sharma, M. Valjavec-Gratian, J. Smith 1997. sfi-independent filamentation in Escherichia coli is lexA dependent and requires DNA damage for induction. J.Bacteriol. 179:1931-1939
- Konola, J.T., A. Guzzo, J.B. Gow, G.C. Walker, K.L. Knight 1998. Differential cleavage of LexA and UmuD mediated by recA Pro67 mutants: implications for common LexA and UmuD binding sites on RecA. J.Mol.Biol. 276:405-415